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Bifunctional reagent

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By Targets:	Bacterial (1) Biochemical Assay Reagents (8) nAChR (1)
By Research Areas:	Neurological Disease (1)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Click Chemistry

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W741573

N-Biotinyl p-aminophenyl arsenic acid	nAChR	Neurological Disease
N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols. N-Biotinyl p-aminophenyl arsenic acid decreases the Rbungarotoxin-binding sites in reduced Torpedo nicotinic receptors (IC₅₀ is 10-300 nM), and protects the receptor from irreversible alkylation by bromoacetylcholine .

HY-132975

PrDiAzK	Bacterial	Others
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT) . PrDiAzK is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-177767

EY-CBS	Biochemical Assay Reagents	Others
EY-CBS is a synthetic and rigid cross linker. EY-CBS reacts selectively with cysteines in a-helices, to stabilize the connecting helix. EY-CBS can be used for the study of the structural stability of protein polypeptides .

HY-W1049129C

Mal-PEG20000-mal	Biochemical Assay Reagents	Others
Mal-PEG20000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG20000-mal can be used for drug delivery .

HY-W1049129B

Mal-PEG10000-mal	Biochemical Assay Reagents	Others
Mal-PEG10000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG10000-mal can be used for drug delivery .

HY-W1048552

Mal-PEG1000-mal	Biochemical Assay Reagents	Others
Mal-PEG1000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG1000-mal can be used for drug delivery .

HY-171561G

DOTAM-Maleimide triTFA	Biochemical Assay Reagents	Others
DOTAM-Maleimide triTFA (GMP) is DOTAM-Maleimide triTFA (HY-171561) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAM-Maleimide triTFA is a bifunctional chelator .

HY-W591975

Alkyne maleimide	Biochemical Assay Reagents	Others
Alkyne maleimide is a bifunctional linker reagent with a terminal malimide group and a propargyl group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

HY-W1049129D

Mal-PEG40000-mal	Biochemical Assay Reagents	Others
Mal-PEG40000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG40000-mal can be used for drug delivery .

HY-W840196

Hex-5-ynehydrazide	Biochemical Assay Reagents	Others
Hex-5-ynehydrazide is a bifunctional linker reagent with a terminal hydrazide group and a propargyl group. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

Cat. No.	Product Name	Type

HY-171561G

DOTAM-Maleimide triTFA	Fluorescent Dyes
DOTAM-Maleimide triTFA (GMP) is DOTAM-Maleimide triTFA (HY-171561) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAM-Maleimide triTFA is a bifunctional chelator .

HY-W840196

Hex-5-ynehydrazide	Fluorescent Dyes
Hex-5-ynehydrazide is a bifunctional linker reagent with a terminal hydrazide group and a propargyl group. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

Mal-PEG20000-mal	Biochemical Assay Reagents
Mal-PEG20000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG20000-mal can be used for drug delivery .

Mal-PEG10000-mal	Biochemical Assay Reagents
Mal-PEG10000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG10000-mal can be used for drug delivery .

Mal-PEG1000-mal	Biochemical Assay Reagents
Mal-PEG1000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG1000-mal can be used for drug delivery .

DOTAM-Maleimide triTFA	Biochemical Assay Reagents
DOTAM-Maleimide triTFA (GMP) is DOTAM-Maleimide triTFA (HY-171561) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAM-Maleimide triTFA is a bifunctional chelator .

Mal-PEG40000-mal	Biochemical Assay Reagents
Mal-PEG40000-mal is a linear bifunctional PEG reagent with reactive maleimide groups. Mal-PEG40000-mal can be used for drug delivery .

Cat. No.	Product Name		Classification

HY-132975

PrDiAzK		Alkynes
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT) . PrDiAzK is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W840196

Hex-5-ynehydrazide		Alkynes
Hex-5-ynehydrazide is a bifunctional linker reagent with a terminal hydrazide group and a propargyl group. The hydrazide group can react with an aldehyde to form a semi-permanent hydrozone bond. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-171561G

DOTAM-Maleimide triTFA	Biochemical Assay Reagents	Others
DOTAM-Maleimide triTFA (GMP) is DOTAM-Maleimide triTFA (HY-171561) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAM-Maleimide triTFA is a bifunctional chelator .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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