5-Azidopentanoic acid
Based on 1 Customer Validation
5-Azidopentanoic acid (5-Azidovaleric acid) is a crosslinker/cyclization reagent as well as an azido-containing carboxylic acid. 5-Azidopentanoic acid participates in CuI-catalyzed azide-alkyne cycloaddition reactions; when used to cap the N-terminus of resin-bound peptides containing propargylglycine residues, it enables head-to-tail cyclodimerization of peptides. 5-Azidopentanoic acid introduces azido functional groups into chitosan via amidation for strain-promoted azide-alkyne cycloaddition click reactions. 5-Azidopentanoic acid acts as an aliphatic bifunctional ligand and capping agent for CdSe tetrapods; its bromo group can be converted to an azido group, which then undergoes catalyst-free alkyne-azide cycloaddition click reactions with ethynyl-terminated poly (3-hexylthiophene).
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 79583-98-5
- Formula: C5H9N3O2
- Molecular Weight:143.14
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
5-Azidopentanoic acid is conjugated with chitosan via an EDC/NHS-mediated amidation reaction to produce azide-modified chitosan, which is confirmed by infrared spectroscopy (IR) and 1H-NMR spectroscopy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 79583-98-5
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Appearance Liquid (Density: 1.142 g/cm3)
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Molecular Weight 143.14
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Formula C5H9N3O2
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Color Light yellow to brown
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SMILES
[N-]=[N+]=NCCCCC(O)=O
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Synonyms
5-Azidovaleric acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (698.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Punna S, et al. Head-to-tail peptide cyclodimerization by copper-catalyzed azide-alkyne cycloaddition. Angew Chem Int Ed Engl. 2005 Apr 8;44(15):2215-20. [Content Brief]
[2]. Gabold B, et al. Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. Drug delivery and translational research. 2023 Mar;13(3):822-838. [Content Brief]
[3]. Jung J, et al. Semiconducting organic-inorganic nanocomposites by intimately tethering conjugated polymers to inorganic tetrapods. Nanoscale. 2016 Apr 28;8(16):8887-98. [Content Brief]
[4]. Cho H, et al. In situ albumin-binding and esterase-specifically cleaved BRD4-degrading PROTAC for targeted cancer therapy. Biomaterials. 2023 Apr;295:122038. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.9862 mL | 34.9308 mL | 69.8617 mL | 174.6542 mL |
| 5 mM | 1.3972 mL | 6.9862 mL | 13.9723 mL | 34.9308 mL | |
| 10 mM | 0.6986 mL | 3.4931 mL | 6.9862 mL | 17.4654 mL | |
| 15 mM | 0.4657 mL | 2.3287 mL | 4.6574 mL | 11.6436 mL | |
| 20 mM | 0.3493 mL | 1.7465 mL | 3.4931 mL | 8.7327 mL | |
| 25 mM | 0.2794 mL | 1.3972 mL | 2.7945 mL | 6.9862 mL | |
| 30 mM | 0.2329 mL | 1.1644 mL | 2.3287 mL | 5.8218 mL | |
| 40 mM | 0.1747 mL | 0.8733 mL | 1.7465 mL | 4.3664 mL | |
| 50 mM | 0.1397 mL | 0.6986 mL | 1.3972 mL | 3.4931 mL | |
| 60 mM | 0.1164 mL | 0.5822 mL | 1.1644 mL | 2.9109 mL | |
| 80 mM | 0.0873 mL | 0.4366 mL | 0.8733 mL | 2.1832 mL | |
| 100 mM | 0.0699 mL | 0.3493 mL | 0.6986 mL | 1.7465 mL |
5-Azidopentanoic acid Related Classifications
HY-130544 Related Classifications
Powered by Bioz
- 5-Azidopentanoic acid
- 79583-98-5
- 5-Azidovaleric acid
- Biochemical Assay Reagents
- strain-promoted azide-alkyne cycloaddition click reactions
- chitosan
- CdSe tetrapods
- glioblastoma
- RGD peptides
- copper(I)-catalyzed azide-alkyne cycloaddition
- BRD4
- PROTAC ARV-771
- ethynyl-terminated poly(3-hexylthiophene)
- propargylglycine
- Inhibitor
- inhibitor
- inhibit