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Art. -Nr.: HY-184176

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DBCO-PEG3-AP1867

DBCO-PEG3-AP1867 is a bifunctional molecular building block that binds to FKBP12^F36V, and also a SPAAC-compatible reagent suitable for synthesizing O-GlcNAcylation-targeting chimeras (OGTACs) against c-Myc. DBCO-PEG3-AP1867 is applicable to cancer-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₆₅H₇₈N₄O₁₅
Molecular Weight:1155.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DBCO-PEG3-AP1867 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

DBCO-PEG3-AP1867 successfully undergoes SPAAC reaction with azide-modified c-Myc-binding oligonucleotides to form a bifunctional OGTAC construct targeting c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) potently induces O-GlcNAcylation of c-Myc and the proximity interaction between c-Myc and OGT in HEK293T-fOGT cells overexpressing Flag-c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (0.1-5 μg/mL; 24 h) significantly reduces the viability of HeLa-fOGT cells^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) remodels the genomic occupancy of c-Myc and significantly downregulates MALAT1 expression in a c-Myc O-GlcNAcylation-dependent manner in HeLa-fOGT cells and HEK293T-fOGT cells overexpressing c-Myc^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1155.33
Formel C₆₅H₇₈N₄O₁₅
SMILES

COC(C=C1)=C(OC)C=C1CC[C@@H](OC([C@H]2N(C([C@@H](CC)C3=CC(OC)=C(OC)C(OC)=C3)=O)CCCC2)=O)C4=CC(OCC(NCCOCCOCCOCCNC(CCC(N5C(C=CC=C6)=C6C#CC(C=CC=C7)=C7C5)=O)=O)=O)=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Xu T, et al. Rewiring c-Myc Transcriptional Activity with an O-GlcNAcylation Targeting Chimera (OGTAC). bioRxiv. 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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