DBCO-PEG3-AP1867 

DBCO-PEG3-AP1867 is a bifunctional molecular building block that binds to FKBP12^F36V, and also a SPAAC-compatible reagent suitable for synthesizing O-GlcNAcylation-targeting chimeras (OGTACs) against c-Myc. DBCO-PEG3-AP1867 is applicable to cancer-related research^[1].

DBCO-PEG3-AP1867 successfully undergoes SPAAC reaction with azide-modified c-Myc-binding oligonucleotides to form a bifunctional OGTAC construct targeting c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) potently induces O-GlcNAcylation of c-Myc and the proximity interaction between c-Myc and OGT in HEK293T-fOGT cells overexpressing Flag-c-Myc^[1].
DBCO-PEG3-AP1867-derived OGTAC (0.1-5 μg/mL; 24 h) significantly reduces the viability of HeLa-fOGT cells^[1].
DBCO-PEG3-AP1867-derived OGTAC (1 μg/mL; 24 h) remodels the genomic occupancy of c-Myc and significantly downregulates MALAT1 expression in a c-Myc O-GlcNAcylation-dependent manner in HeLa-fOGT cells and HEK293T-fOGT cells overexpressing c-Myc^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1155.33

C₆₅H₇₈N₄O₁₅

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu T, et al. Rewiring c-Myc Transcriptional Activity with an O-GlcNAcylation Targeting Chimera (OGTAC). bioRxiv. 2026.