N-Biotinyl p-aminophenyl arsenic acid 

N-Biotinyl p-aminophenyl arsenic acid is a bifunctional reagent that can bind to both streptavidin and dithiols. N-Biotinyl p-aminophenyl arsenic acid decreases the Rbungarotoxin-binding sites in reduced Torpedo nicotinic receptors (IC₅₀ is 10-300 nM), and protects the receptor from irreversible alkylation by bromoacetylcholine^[1].

427.35

C₁₆H₂₂AsN₃O₄S

212391-23-6

Solid

White to off-white

O=[AsH](O)C(C=C1)=CC=C1NC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Moaddel R, et al., Novel biotinylated phenylarsonous acids as bifunctional reagents for spatially close thiols: studies on reduced antibodies and the agonist binding site of reduced Torpedo nicotinic receptors. Bioconjug Chem. 1999 Jul-Aug;10(4):629-37.  [Content Brief]