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  3. Drug Intermediate Drug Derivative
  4. BG-DBCO

BG-DBCO is a DBCO-conjugated Benzylguanine. BG-DBCO, SNAP-E3 fusion protein and Ligand-N3 form a protein complex. BG-DBCO is conjugated with JQ1-N3-C10 to obtain BG-JQ1. BG-JQ1, administered together with SIAH1-SN mRNA, effectively inhibits the growth of small cell carcinoma of the adrenocortical gland.

For research use only. We do not sell to patients.

BG-DBCO

BG-DBCO Chemical Structure

CAS No. : 1820756-74-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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BG-DBCO Related Antibodies

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Description

BG-DBCO is a DBCO-conjugated Benzylguanine. BG-DBCO, SNAP-E3 fusion protein and Ligand-N3 form a protein complex. BG-DBCO is conjugated with JQ1-N3-C10 to obtain BG-JQ1. BG-JQ1, administered together with SIAH1-SN mRNA, effectively inhibits the growth of small cell carcinoma of the adrenocortical gland[1].

Molecular Weight

557.60

Formula

C32H27N7O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC2=C(C(OCC3=CC=C(C=C3)CNC(CCC(N4CC5=C(C#CC6=CC=CC=C46)C=CC=C5)=O)=O)=N1)N=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 11.67 mg/mL (20.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7934 mL 8.9670 mL 17.9340 mL
5 mM 0.3587 mL 1.7934 mL 3.5868 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7934 mL 8.9670 mL 17.9340 mL 44.8350 mL
5 mM 0.3587 mL 1.7934 mL 3.5868 mL 8.9670 mL
10 mM 0.1793 mL 0.8967 mL 1.7934 mL 4.4835 mL
15 mM 0.1196 mL 0.5978 mL 1.1956 mL 2.9890 mL
20 mM 0.0897 mL 0.4484 mL 0.8967 mL 2.2418 mL
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BG-DBCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BG-DBCO1820756-74-8SNAP-DBCODrug IntermediateDrug DerivativeDrug IintermediateDrug derivativesmall cell carcinoma of the adrenocortical glandInhibitorinhibitorinhibit

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