2 Results for "

C5 Lenalidomide-CH3

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "C5 Lenalidomide-CH3" in MCE Product Catalog:

Cat. No.: HY-W586819
CAS No.: 2768326-37-8
Target:  

Ligands for E3 Ligase

Research Areas:  

Cancer

C5 Lenalidomide-CH3 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. C5 Lenalidomide-CH3 can be linked to a target protein ligand via a linker to form a PROTAC.
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1
1 Cited Publications
Cat. No.: HY-P10899
Target:  

PROTACs TGF-beta/Smad

Research Areas:  

Endocrinology

ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC50 value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .
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