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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
CAP-TAC
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "CAP-TAC" in MCE Product Catalog:
Cat. No.: HY-181498
CAS No.: 2375455-59-5
Research Areas:
RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination .
Cat. No.: HY-181499
CAS No.: 2375455-68-6
Target:
Research Areas:
RA190-PEG1-NH2 (Compound S16), RA190 (HY-100739) derivative, is a Proteasome ligand. RA190-PEG1-NH2 can be used to synthesis FKBP12 CAP-TAC degrader RAFKBP12 (HY-181498) .
Cat. No.: HY-181523
CAS No.: 2649154-64-1
Target:
Research Areas:
RA183 is a proteasome ligand that can be used to synthesize CAP-TAC (proteasome cap-targeted chimera), such as RAPRMT5 (HY-181521) .
Cat. No.: HY-181524
Target:
Research Areas:
RA183-CO-C6-NHCO-NH-Boc is a proteasome ligand-linker conjugate that can be used for the synthesis of CAP-TAC (proteasome cap-targeted chimera), such as RAPRMT5 (HY-181521) .
Cat. No.: HY-181521
CAS No.: 2721998-42-9
Research Areas:
RAPRMT5 is a PRMT5 CAP-TAC (proteinase complex-targeted chimeric agent) degrader. RAPRMT5 can induce PRMT5 to undergo proteasome-dependent, ubiquitin-independent degradation. RAPRMT5 can be used in the research of various cancers .
Cat. No.: HY-181495
CAS No.: 2375455-53-9
Research Areas:
RAJQ14 is a BRD4 PROTAC-like CAP-TAC (Proteasome Cap Targeting Chimeras) degrader. RAJQ14 binds to 19S proteasome cap subunits RPN1, RPN10, RPN13, and USP14 to recruit target proteins to the proteasome for ubiquitination-independent, proteasome-dependent degradation. RAJQ14 can be used for the research of cancer (Pink: BRD4 Ligand (HY-181496); Blue: Proteasome Ligand (HY-128978); Black: Linker).
Cat. No.: HY-181500
Research Areas:
AP1867-NH-PEG3-acid (Compound S15) is a Target Protein Ligand-Linker Conjugate that contains the FKBP12 F36V ligand AP1867 (HY-114434) and a PROTAC linker, and recruits E3 ligase. JQ-1-Azidopropylamine is available for the synthesis of PROTAC RAFKBP12 (HY-181498) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
