2375455-59-5
Chemical Structure
RAFKBP12
- CAS No.: 2375455-59-5
- Formula:C79H93Cl4N5O17
- Molecular Weight:1526.42
InChIKey: ZXIIAHZAHZLQSG-ZFQWGETHSA-N
SMILES: O=C([C@@H]1CCCCN1C([C@@H](CC)C2=CC(OC)=C(OC)C(OC)=C2)=O)O[C@@H](C3=CC=CC(OCC(NCCOCCOCCOCCC(NCCOCCN[C@H](C(N4C/C(C(/C(C4)=C/C5=CC(Cl)=C(Cl)C=C5)=O)=C\C6=CC=C(Cl)C(Cl)=C6)=O)CC7=CC=CC=C7)=O)=O)=C3)CCC8=CC(OC)=C(OC)C=C8
Biological Activity: RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination[1].
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RAFKBP12 | RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination. | |||||||||||||||||||||
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Keywords
