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Results for "

D2HG

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-104042
    Vorasidenib
    5+ Cited Publications

    AG-881

    		 Isocitrate Dehydrogenase (IDH) Cancer
    Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K. Vorasidenib can be used for the study of grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1/2 mutation [2].
    Vorasidenib
  • HY-106275
    FX-06

    Fibrin-derived peptide Bβ15-42

    		 Flavivirus Dengue Virus Cardiovascular Disease
    FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS) [2] .
    FX-06
  • HY-156158
    IDH2R140Q-IN-2

    		Isocitrate Dehydrogenase (IDH) Cancer
    IDH2 R140Q-IN-2 (compound 36) is an an orally active IDH2 R140Q inhibitor (IC50: 29 nM). IDH2 R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2 R140Q (IC50: 10 nM). IDH2 R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2 R140Q-IN-2 can be used for research of acute myeloid leukemia (AML) .
    IDH2R140Q-IN-2
  • HY-E71043
    D-2-Hydroxyglutarate Dehydrogenase, Acidaminococcus fermentans

    		Biochemical Assay Reagents Others
    D-2-Hydroxyglutarate Dehydrogenase, Acidaminococcus fermentans (EC 1.1.99.39) is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D-2-hydroxyglutarate (D2HG) to α-ketoglutarate.
    D-2-Hydroxyglutarate Dehydrogenase, Acidaminococcus fermentans
  • HY-145743
    CP-17

    		Isocitrate Dehydrogenase (IDH) Cancer
    CP-17 is a potent and selective IDH2/R140Q inhibitor with an IC50 of 40.75 nM. CP-17 exhibits excellent selectivity of >55-fold against the wild-type IDH2. CP-17 exhibits robust D-2-HG suppression activity in TF-1 (IDH2/R140Q) cells and reverses the cellular differentiation block induced by the R140Q mutation. CP-17 can be used for acute myeloid leukemia (AML) research .
    CP-17
  • HY-104042R
    Vorasidenib (Standard)

    AG-881 (Standard)

    		 Reference Standards Isocitrate Dehydrogenase (IDH) Cancer
    Vorasidenib (Standard) is the analytical standard of Vorasidenib (HY-104042). This product is intended for research and analytical applications. Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K. Vorasidenib can be used for the study of grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1/2 mutation [2].
    Vorasidenib (Standard)

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