1111233-06-7
Chemical Structure
CP-17
- CAS No.: 1111233-06-7
- Formula:C25H25ClN4O2
- Molecular Weight:448.94
IUPAC Name: (1R,2R)-2-(((3aR,4S,7S,7aS)-5-hydroxy-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)methyl-d2)cyclohexane-1-carboxylic-1,2-d2 acid
InChIKey: JOZBIBZIRIKWFL-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(Cl)=CC=C1C)NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2N4CCCC4
Biological Activity: CP-17 is a potent and selective IDH2/R140Q inhibitor with an IC50 of 40.75 nM. CP-17 exhibits excellent selectivity of >55-fold against the wild-type IDH2. CP-17 exhibits robust D-2-HG suppression activity in TF-1 (IDH2/R140Q) cells and reverses the cellular differentiation block induced by the R140Q mutation. CP-17 can be used for acute myeloid leukemia (AML) research[1].
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CP-17 | CP-17 is a potent and selective IDH2/R140Q inhibitor with an IC50 of 40.75 nM. CP-17 exhibits excellent selectivity of >55-fold against the wild-type IDH2. CP-17 exhibits robust D-2-HG suppression activity in TF-1 (IDH2/R140Q) cells and reverses the cellular differentiation block induced by the R140Q mutation. CP-17 can be used for acute myeloid leukemia (AML) research. | |||||||||||||||||||||
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