88650-17-3
Chemical Structure
FX-06
Synonym(s): Fibrin-derived peptide Bβ15-42
- CAS. Nr.: 88650-17-3
- Formula:C133H216N44O38
- Molecular Weight:3039.41
SMILES: C(=O)(N1[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)=O)=O)=O)CO)=O)[C@H](CC)C)=O)CCC2)CCC1)[C@H]4N(C([C@@H](NC(=O)[C@H]5N(C([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]6N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]7N(C([C@@H](NC([C@H](CC8=CN=CN8)NC(CN)=O)=O)CCCNC(=N)N)=O)CCC7)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)CCC6)CO)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC5)C)=O)CCC4
Biological Activity: FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS)[1][2][4].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
FX-06 | 99.73% | FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.78
HY-P10972GIP (22-51) human -
Similarity Score 0.77
HY-P5133Synstatin (92-119) -
Similarity Score 0.75
HY-P3919Adrenotensin (human) -
Similarity Score 0.74
HY-P1912Alpha 1(I) Collagen (614-639), human -
Similarity Score 0.74
HY-P3418CKLF1-C27 -
Similarity Score 0.74
HY-P2556Histone H3 (21-44) -
Similarity Score 0.74
HY-P5110TLQP-21 (human) -
Similarity Score 0.74
HY-P4969Tau Peptide (379-408) -
Similarity Score 0.73
HY-P1366des-Gln14-Ghrelin -
Explore the MedChemAI to find more analogs
References
- [1]. Ahrens I, et al. FX-06, a fibrin-derived Bbeta15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction. Curr Opin Investig Drugs. 2009 Sep;10(9):997-1003. [Content Brief]
- [2]. Zou F, et al. Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening. Bioorg Med Chem Lett. 2018 Feb 1;28(3):388-393. [Content Brief]
- [4]. Gröger M, et al. Peptide Bbeta(15-42) preserves endothelial barrier function in shock. PLoS One. 2009;4(4):e5391. [Content Brief]
