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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
E1/E2
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "E1/E2" in MCE Product Catalog:
26
26 Cited Publications
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PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC50 of < 10 μM, with little activity at E2 and E3.
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NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer [1].
Cat. No.: HY-155157
Purity: 98.66%
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Category:
Cardiovascular Disease Digitalis purpurea Linn. Scrophulariaceae Plants Disease Research Fields Steroids
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Synonyms: BTA074 hydrochloride; AP 611074 hydrochloride
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Teslexivir (BTA074) hydrochloride is a potent antiviral agent. Teslexivir hydrochloride is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir hydrochloride can be used for condyloma research [1].
Cat. No.: HY-109045
CAS No.: 1075798-37-6
Synonyms: BTA074; AP 611074
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Research Areas:
Teslexivir (BTA074) is a potent antiviral agent. Teslexivir is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir can be used for condyloma research [1].
Cat. No.: HY-168397
CAS No.: 23923-84-4
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tetranor-Prostaglandin E1 is metabolite of Prostaglandin E1 (HY-B0131) and Prostaglandin E2 (HY-101952) that is formed by β-oxidation [1].
Cat. No.: HY-155156
Purity: 99.46%
Category:
Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields
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Cat. No.: HY-P701346
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2E1; Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1
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Cat. No.: HY-109045AR
CAS No.: 1075281-70-7
Synonyms: BTA074 hydrochloride (Standard); AP 611074 hydrochloride (Standard)
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Teslexivir hydrochloride (Standard) is the analytical standard of Teslexivir (hydrochloride) (HY-109045A). This product is intended for research and analytical applications. Teslexivir (BTA074) hydrochloride is a potent antiviral agent. Teslexivir hydrochloride is a potent and selective inhibitor of the interaction between two essential viral proteins, E1 and E2, an association that is a necessary step in the DNA replication and thus viral production for Human Papilloma Virus (HPV) 6 and 11. Teslexivir hydrochloride can be used for condyloma research [1].
Cat. No.: HY-P701347
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2E1; Ubiquitin-conjugating enzyme E2 E1; (E3-independent) E2 ubiquitin-conjugating enzyme E1; E2 ubiquitin-conjugating enzyme E1; UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1
Species:
Source:
Cat. No.: HY-E71082
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(E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases.
Cat. No.: HY-L050
495 compounds
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.
MCE offers a unique collection of 495 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.
Cat. No.: HY-L045
4,209 compounds
Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.
HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O2 concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.
MCE offers a unique collection of 4,209 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.
Cat. No.: HY-W654160
Cat. No.: HY-136933R
CAS No.: 4562-36-1
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Cat. No.: HY-W112332A
CAS No.: 197644-96-5
(1E,2E)-1,2-Bis(pyridin-4-ylmethylene)hydrazine is a metal-organic framework (MOF).
Cat. No.: HY-W249353
CAS No.: 960302-57-2
(1E,2E)-1,2-Bis((1H-imidazol-5-yl)methylene)hydrazine is a metal-organic framework (MOF).
Cat. No.: HY-W456359
CAS No.: 1202253-60-8
4,4'-((1E,1'E)-(2,5-Dimethoxy-1,4-phenylene)bis(ethene-2,1-diyl))dibenzoic acid is a metal-organic framework (MOF).
Cat. No.: HY-W456307
CAS No.: 1640127-63-4
Synonyms: 4,4'-[(2,3,5,6-Tetramethyl-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis[pyridine
4,4'-((1E,1'E)-(2,3,5,6-Tetramethyl-1,4-phenylene)bis(ethene-2,1-diyl))dipyridine (4,4'-[(2,3,5,6-Tetramethyl-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis[pyridine) is a metal-organic framework (MOF).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
