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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
EM-12
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "EM-12" in MCE Product Catalog:
1
Target:
Research Areas:
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas .
Cat. No.: HY-164891
CAS No.: 2839138-44-0
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EM12-FS is a cereblon (CRBN) ligand that binds CRBN at His353 and a molecular glue degrader of NTAQ1. EM12-FS has a human plasma half-life of 196 min .
Cat. No.: HY-W760183
CAS No.: 2803819-61-4
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EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells
Cat. No.: HY-159147
CAS No.: 2570251-69-1
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SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC50s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .
Cat. No.: HY-138793R
CAS No.: 26581-81-7
Synonyms: EM-12 (Standard)
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Research Areas:
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Standard) is the analytical standard of 2-(2,6-Dioxopiperidin-3-yl)phthalimidine. This product is intended for research and analytical applications. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas .
Cat. No.: HY-159017
CAS No.: 3094092-95-9
Research Areas:
EM-12-Alkyne-C6-OMs is a conjugate of E3 ligase ligand and linker, consisting of 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12) (HY-138793) and the corresponding Linker (HY-159018). EM-12-Alkyne-C6-OMs can be used to synthesize PROTACs .
Cat. No.: HY-W586108
CAS No.: 2378582-39-7
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EM-12-SH is a Cereblon E3 ligand and can be used for the synthesis of PROTACs, such as SIAIS100 (HY-152036) .
Cat. No.: HY-W591717
CAS No.: 2138440-39-6
Research Areas:
EM-12-alkyne-C3-NH2 is a conjugate of the E3 ligase ligand Lenalidomide-Br (HY-43722) and linker. EM-12-alkyne-C3-NH2 can be conjugated with MI-1061 (HY-125858) to synthesize the PROTAC MD-224 (HY-114312) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
