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Results for "

EMD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (11) Aldehyde Dehydrogenase (ALDH) (1) Angiotensin Receptor (1) Apoptosis (1) Autophagy (5) Bacterial (1) Biochemical Assay Reagents (1) c-Met/HGFR (3) Dopamine Receptor (5) EGFR (1) Factor Xa (1) Integrin (6) Isotope-Labeled Compounds (2) Kinesin (1) Mitochondrial Metabolism (2) Monoamine Oxidase (4) Na+/H+ Exchanger (NHE) (3) Opioid Receptor (2) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (2) Reactive Oxygen Species (2) Serotonin Transporter (7) SGK (3) Sigma Receptor (1) Small Interfering RNA (siRNA) (1) STAT (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (10) Infection (1) Inflammation/Immunology (3) Metabolic Disease (13) Neurological Disease (20)

By Targets:

5-HT Receptor (11)

Aldehyde Dehydrogenase (ALDH) (1)

Angiotensin Receptor (1)

Apoptosis (1)

Autophagy (5)

Bacterial (1)

Biochemical Assay Reagents (1)

c-Met/HGFR (3)

Dopamine Receptor (5)

EGFR (1)

Factor Xa (1)

Integrin (6)

Isotope-Labeled Compounds (2)

Kinesin (1)

Mitochondrial Metabolism (2)

Monoamine Oxidase (4)

Na+/H+ Exchanger (NHE) (3)

Opioid Receptor (2)

PD-1/PD-L1 (1)

Phosphodiesterase (PDE) (2)

Reactive Oxygen Species (2)

Serotonin Transporter (7)

SGK (3)

Sigma Receptor (1)

Small Interfering RNA (siRNA) (1)

STAT (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (10)

Infection (1)

Inflammation/Immunology (3)

Metabolic Disease (13)

Neurological Disease (20)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-106844

EMD 53998	Phosphodiesterase (PDE)	Cardiovascular Disease
EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias .

HY-19134

EMD 56551

5-HT Receptor Neurological Disease

EMD 56551 is a potent and selective 5-HT1A receptor agonist. EMD 56551 exerts anxiolytic activity .

EMD 56551	5-HT Receptor	Neurological Disease
EMD 56551 is a potent and selective 5-HT1A receptor agonist. EMD 56551 exerts anxiolytic activity .

HY-103247

EMD 66684	Angiotensin Receptor	Cardiovascular Disease
EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC₅₀ value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant ^- .

HY-10777

EMD 495235	Factor Xa	Cardiovascular Disease
EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC₅₀ of 5.5 nM and a K_i of 6.8 nM. EMD 495235 shows anticoagulant activities .

HY-114990

EMD 57439	Phosphodiesterase (PDE)	Cardiovascular Disease
EMD 57439 is a selective PDE-III inhibitor. EMD 57439 does not significantly increase c-AMP concentration and has little effect on Ca(50) .

HY-103130

EMD386088	5-HT Receptor	Neurological Disease
EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induces cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia .

HY-106150B

Eniporide hydrochloride 1 Publications Verification EMD-96785 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na ⁺/H ⁺ exchange inhibitor.

HY-15193A

EMD638683 R-Form

2 Publications Verification

SGK Metabolic Disease

EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC₅₀ of 3 μM.
HY-15193B

EMD638683 S-Form

SGK Metabolic Disease

EMD638683 S-Form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC₅₀ of 3 μM.

EMD638683 R-Form 2 Publications Verification	SGK	Metabolic Disease
EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC₅₀ of 3 μM.

EMD638683 S-Form	SGK	Metabolic Disease
EMD638683 S-Form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC₅₀ of 3 μM.

HY-19273A

Rimeporide hydrochloride EMD-87580 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-19273

Rimeporide 1 Publications Verification EMD-87580	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-P0322

GRGDSPK EMD 56574	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption .

HY-101473

EMD527040	Integrin	Inflammation/Immunology
EMD527040 is a potent and highly selective αvβ6 antagonist with antifibrotic activities. EMD527040 can be used for carcinoma and liver fibrosis research .

HY-103410

Carmoxirole hydrochloride EMD 45609 hydrochloride	Dopamine Receptor	Cardiovascular Disease
Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective, peripherally acting dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo .

HY-P9969

Matuzumab

EMD 72000
EGFR Cancer

Matuzumab (EMD 72000) is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth .
HY-15193

EMD638683

10+ Cited Publications

SGK Metabolic Disease Cancer

EMD638683 is a highly selective SGK1 inhibitor, with an IC₅₀ value of 3 μM.
HY-15000

EMD534085

Kinesin Cancer

EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC₅₀ of 8 nM.

Matuzumab EMD 72000	EGFR	Cancer
Matuzumab (EMD 72000) is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth .

EMD638683 10+ Cited Publications	SGK	Metabolic Disease Cancer
EMD638683 is a highly selective SGK1 inhibitor, with an IC₅₀ value of 3 μM.

EMD534085	Kinesin	Cancer
EMD534085 is a potent and selective inhibitor of the mitotic kinesin-5 with an IC₅₀ of 8 nM.

HY-14771A

Imeglimin hydrochloride 3 Publications Verification EMD 387008 hydrochloride	Mitochondrial Metabolism Reactive Oxygen Species	Metabolic Disease
Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function .

HY-136280

Panamesine EMD 57445	Sigma Receptor	Neurological Disease
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC₅₀ 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent .

HY-100820

Sarizotan EMD 128130	5-HT Receptor Dopamine Receptor	Neurological Disease
Sarizotan (EMD 128130) is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC₅₀ values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively .

HY-14261

Vilazodone Hydrochloride 3 Publications Verification EMD 68843 Hydrochloride; SB659746A Hydrochloride	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT_1A receptor partial agonist.

HY-14771

Imeglimin EMD 387008	Mitochondrial Metabolism Reactive Oxygen Species	Metabolic Disease
Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function .

HY-14721

Tepotinib 5 Publications Verification EMD-1214063	c-Met/HGFR Autophagy	Cancer
Tepotinib (EMD-1214063) is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC₅₀ of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib inhibits c-Met phosphorylation and induces autophagy. Tepotinib has antitumor effects .

HY-14721A

Tepotinib hydrochloride EMD-1214063 hydrochloride	c-Met/HGFR Autophagy	Cancer
Tepotinib (EMD-1214063) hydrochloride is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC₅₀ of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib hydrochloride inhibits c-Met phosphorylation and induces autophagy. Tepotinib hydrochloride has antitumor effects .

HY-RS04345

EMD Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EMD Human Pre-designed siRNA Set A contains three designed siRNAs for EMD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EMD Human Pre-designed siRNA Set A EMD Human Pre-designed siRNA Set A

HY-107384

Asimadoline EMD-61753	Opioid Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
Asimadoline (EMD-61753) is an orally active, selective and peripherally active κ-opioid agonist with IC₅₀s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS) .

HY-107384A

Asimadoline hydrochloride EMD-61753 hydrochloride	Opioid Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC₅₀s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS) .

HY-P0322A

GRGDSPK TFA EMD 56574 TFA	Integrin	Cardiovascular Disease Metabolic Disease
GRGDSPK TFA (EMD 56574 TFA) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK TFA is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK TFA is used to study the role of integrins in bone formation and resorption .

HY-106246

Pruvanserin EMD 281014 free acid; LY 2422347	5-HT Receptor	Neurological Disease Metabolic Disease
Pruvanserin (EMD 281014 free acid) is a selective 5-HT2A receptor antagonist. Pruvanserin alleviates tactile allodynia in diabetic rats. Pruvanserin can also be used for research of insomnia .

HY-106100

Roxindole EMD 49980	Dopamine Receptor Serotonin Transporter	Neurological Disease
Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT_1A agonist and 5-HT uptake inhibitor. Antipsychotic and antidepressant activities .

HY-103115

Pruvanserin hydrochloride EMD 281014; LY 2422347 hydrochloride	5-HT Receptor	Neurological Disease
Pruvanserin hydrochloride (EMD 281014) is a selective serotonin 5-HT_2A receptor antagonist with IC₅₀ values of 0.35 nM and 1 nM for human and rat 5-HT_2A receptors. Pruvanserin (hydrochloride) can be used for the research of schizophrenia .

HY-14262

Vilazodone 3 Publications Verification EMD 68843; SB659746A	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .

HY-106100A

Roxindole hydrochloride EMD 38362	Dopamine Receptor Serotonin Transporter	Neurological Disease
Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT_1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT_1A (IC₅₀=0.9 nM). Antipsychotic and antidepressant activities .

HY-16141

Cilengitide Maximum Cited Publications 39 Publications Verification EMD 121974	Integrin Autophagy Apoptosis STAT PD-1/PD-L1	Cancer
Cilengitide (EMD 121974) is a potent integrins antagonist with IC₅₀s of 0.61 nM (α_νβ₃), 8.4 nM (α_νβ₅) and 14.9 nM (α₅β₁), respectively. Cilengitide inhibits the binding of α_νβ₃ and α_νβ₅ to Vitronectin with IC₅₀s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers .

HY-106150

Eniporide EMD-96785	Biochemical Assay Reagents	Others
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

HY-70057A

Safinamide mesylate 2 Publications Verification FCE 26743 mesylate; EMD 1195686 mesylate	Monoamine Oxidase	Cardiovascular Disease Neurological Disease
Safinamide (FCE 26743; EMD 1195686) mesylate is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.098 µM) over MAO-A (IC₅₀=580 nM) . Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8 µM) than at resting (IC₅₀=262 µM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke et.al .

HY-14262S1

Vilazodone-d8 hydrochloride EMD 68843-d8; SB659746A-d8	5-HT Receptor Serotonin Transporter Isotope-Labeled Compounds	Neurological Disease
Vilazodone-d₈ hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active?serotonin?reuptake inhibitor (SSRI) and partial?5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .

HY-106472

Tioxaprofen EMD 26644	Bacterial	Infection
Tioxaprofen is a new anti-mycotic drug against Trichophyton mentagrophytes and T. rubrum, and is a potent uncoupling agent of mitochondrial respiration .

HY-16143

Cilengitide TFA Maximum Cited Publications 39 Publications Verification EMD 121974 TFA	Integrin Autophagy	Cancer
Cilengitide is a potent and selective integrin inhibitor for α_vβ₃ and α_vβ₅ receptor, with IC₅₀ values of 4 nM and 79 nM, respectively.

HY-70057

Safinamide 2 Publications Verification FCE 26743; EMD 1195686	Monoamine Oxidase	Neurological Disease
Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.098 µM) over MAO-A (IC₅₀=580 µM) . Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8 µM) than at resting (IC₅₀=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al .

HY-P99183

Abituzumab EMD 525797; DI17E6	Integrin	Cancer
Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer .

HY-107030

Nitrefazole EMD-15700	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.

HY-70057S1

Safinamide-d4-1 FCE 26743-d₄-1; EMD 1195686-d₄-1	Isotope-Labeled Compounds Monoamine Oxidase	Neurological Disease
Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].

HY-106844A

*(+)-EMD* 57033**	Others	Cardiovascular Disease
(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca ²⁺ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function .

HY-14203

(R)-Safinamide FCE 28073; (R)-EMD 1195686	Monoamine Oxidase	Neurological Disease
(R)-Safinamide, the enantiomer of safinamide (HY-70057), can inhibit MAO-B with an IC₅₀ value of 0.45 μM .

HY-14721R

Tepotinib (Standard)	c-Met/HGFR Autophagy	Cancer
Tepotinib (Standard) is the analytical standard of Tepotinib. This product is intended for research and analytical applications. Tepotinib (EMD-1214063) is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC₅₀ of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib inhibits c-Met phosphorylation. Tepotinib has antitumor effects .

HY-14261R

Vilazodone Hydrochloride (Standard)	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone (Hydrochloride) (Standard) is the analytical standard of Vilazodone (Hydrochloride). This product is intended for research and analytical applications. Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT_1A receptor partial agonist.

HY-100820R

Sarizotan (Standard)	5-HT Receptor Dopamine Receptor	Neurological Disease
Sarizotan (Standard) is the analytical standard of Sarizotan. This product is intended for research and analytical applications. Sarizotan (EMD 128130) is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC₅₀ values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively .

HY-14262R

Vilazodone (Standard)	5-HT Receptor Serotonin Transporter	Neurological Disease
Vilazodone (Standard) is the analytical standard of Vilazodone. This product is intended for research and analytical applications. Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT₁A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders .

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