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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
ETS1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "ETS1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P70292
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ETS1; FLJ10768; Prev. EWSR2; V-ETS Avian Erythroblastosis Virus E2 Oncogene Homolog 1; ETS-1; ETS1 Protein; Avian Erythroblastosis Virus E26 (V-ETS) Oncogene Homolog-1; ETS Protein; V-ETS Avian Erythroblastosis Virus E26 Oncogene Homolog 1; C-ETS-1; Prote
Cat. No.: HY-W002199
CAS No.: 647-42-7
Synonyms: 6:2 FTOH; 1H,1H,2H,2H-Perfluoro-1-octanol; 2-(Perfluorohexyl)ethanol
Target:
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6:2 Fluorotelomer alcohol (6:2 FTOH) is an orally active, blood-brain barrier-permeable modulator of cyclin D1 and ETS1. 6:2 Fluorotelomer alcohol downregulates cyclin D1 expression, upregulates ETS1 via the TNF-α/ERK 1/2 pathway, impairs mitochondrial membrane potential and respiratory function, increases reactive oxygen species levels, disrupts calcium homeostasis and activates endoplasmic reticulum stress markers, and induces cell proliferation inhibition and endothelial-mesenchymal transition. Furthermore, 6:2 Fluorotelomer alcohol induces morphological abnormalities in zebrafish embryos and liver developmental damage, while disrupting the brain immune microenvironment in mice, causing systemic toxicity and delayed pup maturation in CD-1 mice. 6:2 Fluorotelomer alcohol also induces cortical neuron apoptosis, glial cell activation, synaptic abnormalities, colonic barrier damage, intestinal dysbiosis and autism spectrum disorder-like symptoms in mice. 6:2 Fluorotelomer alcohol shows no mutagenic, clastogenic, primary skin/eye irritation or skin sensitizing effects, exhibits no selective reproductive toxicity in CD-1 mice, and is classified as GHS Category 4 for acute oral toxicity. 6:2 Fluorotelomer alcohol can be used in studies of neurodevelopmental disorders and autism spectrum disorders [1] .
Cat. No.: HY-RS04562
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ETS1 Human Pre-designed siRNA Set A contains three designed siRNAs for ETS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16879
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Ets1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ets1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23321
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Ets1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ets1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P82749A
Synonyms: ETS1; EWSR2; Protein C-ETS-1; p54
Cat. No.: HY-RS28129
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Kcnh8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Kcnh8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P83109A
Synonyms: DAXX; BING2; DAP6; Death domain-associated protein 6; Daxx; hDaxx; ETS1-associated protein 1; EAP1; Fas death domain-associated protein
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
