ETS1 Antibody (YA2494)
(Synonyms: ETS1; EWSR2; Protein C-ets-1; p54)ETS1 Antibody (YA2494) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ETS1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
ETS1 Antibody (YA2494) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ETS1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 50 kDa
Entrez Gene: 2113 Human ; 23871 Mouse ; 24356 Rat
SwissProt: P14921 Human ; P27577 Mouse ; P41156 Rat
OMIM: 164720 Human
A synthetic peptide of human ETS1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ETS1 transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion; Acts as a dominant-negative for isoform c-ETS-1A[1][2][3][4][5].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_specificity:It is highly expressed in lymphocytes. Both c-ETS-1A and Ets-1 p27 subtypes were detected in all fetal tissues tested, but in human tissues, the variation varied depending on the tissue type. It was not detected in brain tissue or kidneys.
Induction:Up-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at protein level) -
Isoforms & Post-Translational Modification
P14921 has 5 isomers: P14921-1: 50408 Da (predicted); P14921-2: 40786 Da (predicted); P14921-3: 55412 Da (predicted); P14921-4: 25697 Da (predicted); P14921-5: 30860 Da (predicted).
Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity;Ubiquitinated; which induces proteasomal degradation;Phosphorylation at Ser-251, Ser-282 and Ser-285 by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA: an increasing number of phosphoserines causes DNA-binding to become progressively weaker -
Subunit
Binds DNA as a homodimer; homodimerization is required for transcription activation (PubMed:18566588). Interacts with MAF and MAFB (By similarity). Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX (PubMed:10698492). Interacts with UBE2I (PubMed:9333025). Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity (PubMed:11909962, PubMed:15247905)
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SwissProt ID
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Synonyms
ETS1; EWSR2; Protein C-ets-1; p54
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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