6 Results for "

Emodin (Standard)

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "Emodin (Standard)" in MCE Product Catalog:

Emodin (Standard)
Emodin (Standard)
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Cat. No.: HY-14393R
CAS No.: 518-82-1
Synonyms: Frangula Emodin (Standard)
Category:  

Quinones Rheum palmatum L. Polygonaceae Phenols Plants Disease Research Fields Cancer

Target:  

Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD

Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .
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Aloe emodin (Standard)
Aloe emodin (Standard)
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Cat. No.: HY-N0189R
CAS No.: 481-72-1
Synonyms: Rhabarberone (Standard); 3-Hydroxymethylchrysazine (Standard)
Category:  

Quinones Liliaceae Aloe vera (L.) Burm. f. Phenols Plants Disease Research Fields Cancer

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Reference Standards Autophagy

Aloe emodin (Standard) is the analytical standard of Aloe emodin. This product is intended for research and analytical applications.
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Emodin-8-glucoside (Standard)
Emodin-8-glucoside (Standard)
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Cat. No.: HY-N0311R
CAS No.: 23313-21-5
Category:  

Quinones other families Anthraquinones Phenols Polyphenols Plants

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Reference Standards Aldose Reductase Topoisomerase SOD p38 MAPK

Emodin-8-glucoside (Standard) is the analytical standard of Emodin-8-glucoside. This product is intended for research and analytical applications. Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .
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Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
Aloe-emodin-8-O-β-D-glucopyranoside (Standard)
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Cat. No.: HY-N2451R
CAS No.: 33037-46-6
Category:  

Quinones Liliaceae Monophenols Anthraquinones Aloe vera (L.) Burm. f. Phenols Plants

Target:  

Reference Standards Phosphatase

Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC50 of 26.6 μM .
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Aloin B (Standard)
Aloin B (Standard)
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Cat. No.: HY-N0886R
CAS No.: 28371-16-6
Synonyms: Isobarbaloin (Standard)
Category:  

Quinones Liliaceae Anthraquinones Aloe vera (L.) Burm. f. Phenols Polyphenols Plants

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Reference Standards Virus Protease SARS-CoV

Aloin B (Isobarbaloin) (Standard) is the analytical standard of Aloin B. This product is intended for research and analytical applications. Aloin B is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation .
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Emodinanthrone (Standard)
Emodinanthrone (Standard)
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Cat. No.: HY-N9362R
CAS No.: 491-60-1
Synonyms: EmodAN (Standard)
Category:  

Phenols Polyphenols Plants Rhamnaceae Aconitum nagarum var. acaule (Finet & Gagnep.) Q. E. Yang

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Reference Standards Antibiotic Ferroptosis

Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Emodinanthrone (EmodAn) is a MARCH7 stabilizer that inhibits ferroptosis (EC50=70 nM). Emodinanthrone is also a precursor to Emodin (HY-14393) and possesses antibiotic activity. Emodinanthrone directly binds to MARCH7 and blocks its ubiquitination-mediated degradation at the K608 site; this action enhances MARCH7-mediated K48 ubiquitination and degradation of NCOA4, as well as its regulation of the intracellular localization of TFR1 via K63 ubiquitination, thereby reducing the intracellular labile iron pool and blocking ferroptosis. Emodinanthrone demonstrates in vivo cardioprotective effects and exhibits a favorable safety profile. Emodinanthrone is applicable to research on ferroptosis-related cardiovascular diseases, including Doxorubicin (HY-15142A)-induced cardiomyopathy and myocardial ischemia-reperfusion injury .
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