23313-21-5
Chemical Structure
Emodin-8-glucoside
- CAS No.: 23313-21-5
- Formula:C21H20O10
- Molecular Weight:432.38
IUPAC Name: 1,6-dihydroxy-3-methyl-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)anthracene-9,10-dione
InChIKey: HSWIRQIYASIOBE-JNHRPPPUSA-N
SMILES: O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C13)=O
Biological Activity: Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier[1][2][3][4][5].
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Emodin-8-glucoside | 99.35% | Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier. | ||||||||||||||||||||
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Emodin-8-glucoside (Standard) | ≥98% | Emodin-8-glucoside (Standard) is the analytical standard of Emodin-8-glucoside. This product is intended for research and analytical applications. Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier. | ||||||||||||||||||||
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- [1]. Kim J M, et al. Constituents of the fruits of Rumex japonicus with Inhibitory Activity on Aldose Reductase[J]. Journal of Applied Biological Chemistry, 2008, 51(1): 13-16.
- [2]. Hwangbo K, et al., Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica. Arch Pharm Res. 2012 Sep;35(9):1583-9. [Content Brief]
- [3]. Wang C, et al., Neuroprotective effects of emodin-8-O-beta-D-glucoside in vivo and in vitro. Eur J Pharmacol. 2007 Dec 22;577(1-3):58-63. [Content Brief]
- [4]. Zhang K, et al., Discovery of Natural Products Alleviating Renal Fibrosis with a Viscosity-Responsive Molecular Probe. Anal Chem. 2024 Apr 23;96(16):6356-6365. [Content Brief]
- [5]. Vaziri-Amjad S, et al., Natural anthraquinones as promising MAPK3 inhibitors for complementary cancer therapy[J]. Journal of Chemistry, 2023, 2023(1): 6683470.
