2 Results for "

Epiberberine

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Epiberberine" in MCE Product Catalog:

Epiberberine
Epiberberine
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Cat. No.: HY-N0226
CAS No.: 6873-09-2
Category:  

Alkaloids Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) Beta-secretase

Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC50, 16.83 μM), and can be used for the research of Alzheimer disease . Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberinecan be used for the research of diabetic disease .
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4
Epiberberine chloride
Epiberberine chloride
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4 Cited Publications
Cat. No.: HY-N0226A
CAS No.: 889665-86-5
Category:  

Alkaloids Neurological Disease Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species (ROS)

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .
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