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FLIPR assay

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10835
    DG-041
    3 Publications Verification

    		 Prostaglandin Receptor Cardiovascular Disease
    DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier .
    DG-041
  • HY-10898
    SB-674042
    2 Publications Verification

    		 Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd=5.03 nM), exhibits 100-fold selectivity for OX1 over OX2 receptors with IC50 values of 3.76 nM and 531 nM, respectively .
    SB-674042
  • HY-133011
    nAChR agonist 1

    		nAChR Neurological Disease
    nAChR agonist 1 is a potent, blood-brain-barrier-permeable, and orally active allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 μM in a Ca 2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease .
    nAChR agonist 1
  • HY-120636
    P2Y1 antagonist 1

    		P2Y Receptor Cardiovascular Disease
    P2Y1 antagonist 1 (compound 10q) is a potent antagonist of P2Y1, with the IC50s of 1.1 nM and 0.24 μM in FLIPR assay and hPA assay, respectively. P2Y1 antagonist 1 plays an important role in antiplatelet research .
    P2Y1 antagonist 1
  • HY-14232
    TTA-A8

    		Calcium Channel Neurological Disease
    TTA-A8 (Compound 13) is a short-acting T-type calcium channel antagonist with oral activity, exhibiting an IC50 value of 31.3 nM in the FLIPR depolarization assay. TTA-A8 possesses favorable pharmacokinetic properties, making it suitable for research on epilepsy and sleep .
    TTA-A8
  • HY-10835R
    DG-041 (Standard)

    		Reference Standards Prostaglandin Receptor Cardiovascular Disease
    DG-041 (Standard) is the analytical standard of DG-041 (HY-10835). This product is intended for research and analytical applications. DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier .
    DG-041 (Standard)
  • HY-180584
    5-HT2A agonist 9

    		5-HT Receptor Neurological Disease
    5-HT2A agonist 9 (Compound I-53) is a 5-HT2A agonist with an EC₅₀ of 34 nM. 5-HT2A agonist 9 can be used for the study of mental disorders and central system disorders .
    5-HT2A agonist 9
  • HY-10898R
    SB-674042 (Standard)

    		Reference Standards Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    SB-674042 (Standard) is the analytical standard of SB-674042 (HY-10898). This product is intended for research and analytical applications. SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd=5.03 nM), exhibits 100-fold selectivity for OX1 over OX2 receptors with IC50 values of 3.76 nM and 531 nM, respectively .
    SB-674042 (Standard)

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