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Cat. No.: HY-186257

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TMEM175 agonist 3

TMEM175 agonist 3 (Compound 123) is a TMEM175 agonist, with an EC₅₀ of 0.044 μM in human TMEM175 FLIPR assays and an EC₅₀ of 0.073 μM in human TMEM175 EP assays. TMEM175 agonist 3 can be used in the research of Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases.

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CAS No.: 3129652-66-7
화학식: C₂₄H₂₁N₅O₄S
분자량:475.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TMEM175 agonist 3 Chemical Structure

CAS No.: 3129652-66-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
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Biological Activity

제품 설명

In Vitro

TMEM175 is a bifunctional channel protein on the lysosomal membrane with both proton and potassium ion permeability. It maintains lysosomal homeostasis and α-synuclein degradation, and its loss-of-function mutations significantly increase the risk of Parkinson's disease.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3129652-66-7
분자량 475.52
화학식 C₂₄H₂₁N₅O₄S
SMILES

O=C1N(NS(C2=CC3=C(C=CN3)C=C2)(=O)=O)C([C@@H](C4=CC=CC=C4)OC)=NC5=C1C=CN=C5C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. CHAPMAN, Mark Love, et al. Novel sulfonamide derivatives. WO2026104679 A1 2026-05-21.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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