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GLS2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (3) Biochemical Assay Reagents (1) Glutaminase (9) Reference Standards (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (9) Inflammation/Immunology (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12248

Telaglenastat 100+ Cited Publications CB-839	Glutaminase Autophagy	Cancer
Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits *GLS1* splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity .

HY-103671

IPN60090	Glutaminase	Inflammation/Immunology Cancer
IPN-60090 is an orally active and highly selective inhibitor of glutaminase 1 (GLS1; IC₅₀=31 nM), with no activity observed against GLS-2. IPN-60090 exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 can be used for solid tumors research, such as lung and ovarian cancers ^[2].

HY-103671A

IPN60090 dihydrochloride	Glutaminase	Inflammation/Immunology Cancer
IPN-60090 dihydrochloride is an orally active and highly selective inhibitor of glutaminase 1 (GLS1; IC₅₀=31 nM), with no activity observed against GLS-2. IPN-60090 dihydrochloride exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 dihydrochloride can be used for solid tumors research, such as lung and ovarian cancers ^[2].

HY-P2760

Glutaminase GLS	Biochemical Assay Reagents Glutaminase	Cancer
Glutaminase is a metabolic enzyme. Glutaminase catalyzes the hydrolysis of glutamine to glutamate. Glutaminase isoenzymes are encoded by Gls and Gls2 genes. Proteins GLS and GLS2 have different kinetic, immunologic, and molecular characteristics. Glutaminase can be used in the research of cancer ^[2].

HY-12248R

Telaglenastat (Standard) CB-839 (Standard)	Glutaminase Autophagy Reference Standards	Cancer
Telaglenastat (Standard) is the analytical standard of Telaglenastat. This product is intended for research and analytical applications. Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity .

HY-RS05503

GLS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GLS2 Human Pre-designed siRNA Set A contains three designed siRNAs for GLS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GLS2 Human Pre-designed siRNA Set A GLS2 Human Pre-designed siRNA Set A

HY-RS24276

Gls2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gls2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gls2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gls2 Rat Pre-designed siRNA Set A Gls2 Rat Pre-designed siRNA Set A

HY-RS17808

Gls2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gls2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gls2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gls2 Mouse Pre-designed siRNA Set A Gls2 Mouse Pre-designed siRNA Set A

HY-151434

GLS1 Inhibitor-6	Glutaminase Apoptosis	Cancer
GLS1 Inhibitor-6 (Compound 24y) is an orally active, potent and selective glutaminase 1 (GLS1) inhibitor (IC₅₀=68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces apoptosis .

HY-12248A

Telaglenastat hydrochloride CB-839 hydrochloride	Glutaminase Autophagy	Cancer
Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride selectively inhibits *GLS1* splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat hydrochloride inudces autophagy and has antitumor activity .

HY-103671AR

IPN60090 dihydrochloride (Standard)	Reference Standards Glutaminase	Inflammation/Immunology Cancer
IPN60090 dihydrochloride (Standard) is the analytical standard of IPN60090 dihydrochloride (HY-103671A). This product is intended for research and analytical applications. IPN-60090 dihydrochloride is an orally active and highly selective inhibitor of glutaminase 1 (GLS1; IC₅₀=31 nM), with no activity observed against GLS-2. IPN-60090 dihydrochloride exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 dihydrochloride can be used for solid tumors research, such as lung and ovarian cancers ^[2].

HY-103671R

IPN60090 (Standard)	Reference Standards Glutaminase	Inflammation/Immunology Cancer
IPN60090 (Standard) is the analytical standard of IPN60090 (HY-103671). This product is intended for research and analytical applications. IPN-60090 is an orally active and highly selective inhibitor of glutaminase 1 (GLS1; IC₅₀=31 nM), with no activity observed against GLS-2. IPN-60090 exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 can be used for solid tumors research, such as lung and ovarian cancers ^[2].

Host:	Mouse (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) WB (3)
Isotype:	IgG1 (1) IgG2a (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88072

	GLS2 Antibody (YA7756) GA; GLS; hLGA; LGA	WB, IHC-P	Human, Mouse, Rat
	GLS2 Antibody (YA7756) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GLS2.

HY-P88072A

	GLS2 Antibody (YA7756)(PBS only) GA; GLS; hLGA; LGA	WB, IHC-P	Human, Mouse, Rat
	GLS2 Antibody (YA7756) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GLS2.

HY-P87274

	GLS2 Antibody (YA6957) breast cell glutaminase antibody; GA antibody; GLS antibody; GLS2 antibody; GLSL_HUMAN antibody; glutaminase 2 (liver mitochondrial) antibody; glutaminase 2 antibody; glutaminase GA antibody; glutaminase I antibody; Glutaminase liver isoform antibody	WB, IHC-P	Human, Mouse, Rat
	GLS2 Antibody (YA6957) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GLS2.

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GLS2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GLS2 Human Pre-designed siRNA Set A contains three designed siRNAs for GLS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gls2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gls2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gls2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gls2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gls2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gls2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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