9001-47-2
9001-47-2
Chemical Structure
Glutaminase
Synonym(s): GLS
- CAS No.: 9001-47-2
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Glutaminase]
Biological Activity: Glutaminase (GLS) is a metabolic enzyme. Glutaminase catalyzes the conversion of glutamine to glutamate, which is a key step in glutaminolysis. The glutaminase isoenzymes GLS and GLS2 differ in their expression patterns and functional roles: GLS exhibits oncogenic properties, whereas GLS2 is regarded as a tumor suppressor. Glutaminase expression levels correlate with the degree of tumor malignancy[1][2].
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Glutaminase | Glutaminase (GLS) is a metabolic enzyme. Glutaminase catalyzes the conversion of glutamine to glutamate, which is a key step in glutaminolysis. The glutaminase isoenzymes GLS and GLS2 differ in their expression patterns and functional roles: GLS exhibits oncogenic properties, whereas GLS2 is regarded as a tumor suppressor. Glutaminase expression levels correlate with the degree of tumor malignancy. | |||||||||||||||||||||
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References
- [1]. Matés JM, et al. Glutaminase isoenzymes in the metabolic therapy of cancer. Biochimica et biophysica acta. Reviews on cancer. 2018 Dec;1870(2):158-164. [Content Brief]
- [2]. Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer cell. 2010 Sep 14;18(3):207-19. [Content Brief]
