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GMBS

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W041994
    GMBS

    		Fructose-1,6-bisphosphate aldolase Biochemical Assay Reagents Cancer
    GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins .
    GMBS
  • HY-107783
    Sulfo-GMBS

    		Biochemical Assay Reagents Others
    Sulfo-GMBS is a crosslinker widely used in chemical modification and coupling reactions of proteins and peptides. Among amine-thiol crosslinkers, Sulfo-GMBS generates the largest number of crosslinks and covers most of the crosslinks identified by AMAS and GMBS .
    Sulfo-GMBS
  • HY-125834
    GMB-475

    		PROTACs Bcr-Abl Apoptosis STAT JAK Cancer
    GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau (VHL). GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. (Blue: VHL ligand (HY-125845); Black: Linker; Pink: BCR-ABL1 ligand (HY-11007)) .
    GMB-475
  • HY-125845
    (S,R,S)-AHPC
    2 Publications Verification

    VH032-NH2; VHL ligand 1

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells .
    (S,R,S)-AHPC
  • HY-130297
    PROTAC BCR-ABL1 ligand 1

    		Bcr-Abl Ligands for Target Protein for PROTAC Cancer
    PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1 .
    PROTAC BCR-ABL1 ligand 1
  • HY-110402
    (S,R,S)-AHPC TFA

    VH032-NH2 TFA; VHL ligand 1 TFA

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC (VH032-NH2) TFA is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells .
    (S,R,S)-AHPC TFA
  • HY-130997
    17-GMB-APA-GA

    		ADC Payload HSP Infection Cancer
    17-GMB-APA-GA is an ADC Cytotoxin. 17-GMB-APA-GA is a potent HSP90 inhibitor and used for latent T. gondii infection research .
    17-GMB-APA-GA
  • HY-101763B
    (S,R,S)-AHPC dihydrochloride

    VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride

    		 Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC (VH032-NH2) dihydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC dihydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells .
    (S,R,S)-AHPC dihydrochloride
  • HY-180968
    GMB-805

    		PROTACs Bcr-Abl Cancer
    GMB-805 is a BCR-Abl PROTAC degrader with a DC50 of 30 nM in K562 cells. GMB-805 exerts antiproliferative activity in K562 cells. GMB-805 exhibits potent anti-tumor activity with favorable safety profile in vivo. GMB-805 can be used for chronic myeloid leukemia research .
    GMB-805

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