2489876-41-5
2489876-41-5
Chemical Structure
GMB-805
- CAS No.: 2489876-41-5
- Formula:C42H46ClF2N9O7S
- Molecular Weight:894.39
InChIKey: ZZAMCOWPQNSLBF-CPIPLPSASA-N
SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(COCCNC4=C(C5=NNC=C5)C=C(C=N4)C(NC6=CC=C(C=C6)OC(F)(F)Cl)=O)=O
Biological Activity: GMB-805 is a BCR-Abl PROTAC degrader with a DC50 of 30 nM in K562 cells. GMB-805 exerts antiproliferative activity in K562 cells. GMB-805 exhibits potent anti-tumor activity with favorable safety profile in vivo. GMB-805 can be used for chronic myeloid leukemia research[1][2].
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GMB-805 | GMB-805 is a BCR-Abl PROTAC degrader with a DC50 of 30 nM in K562 cells. GMB-805 exerts antiproliferative activity in K562 cells. GMB-805 exhibits potent anti-tumor activity with favorable safety profile in vivo. GMB-805 can be used for chronic myeloid leukemia research. | |||||||||||||||||||||
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References
- [1]. Burslem GM, et al. Scaffold hopping enables direct access to more potent PROTACs with in vivo activity. Chem Commun (Camb). 2020 Jun 23;56(50):6890-6892. [Content Brief]
- [2]. Chen X, et al. Mighty mini-PROTACs: an emerging class of degraders. Eur J Med Chem. 2026 Jan 5;301:118202. [Content Brief]
Keywords
