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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
Gas+6
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "Gas+6" in MCE Product Catalog:
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10 Publications Verification
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LDC1267 is a AXL/TAM/FLT3 inhibitor with IC50 values of 42 nM, 130 nM, and 63 nM against AXL, MERTK, and TYRO3, respectively. LDC1267 blocks GAS6-induced AXL phosphorylation and the downstream AKT/ERK1/2 signaling pathway. LDC1267 inhibits cancer cell proliferation, colony formation, and glioblastoma cell invasion, without causing obvious impairment of cytotoxic autophagic flux. LDC1267 exerts a synergistic effect when used in combination with Imatinib (HY-15463) in chronic myeloid leukemia models. LDC1267 can be widely applied in studies related to glioblastoma and chronic myeloid leukemia .
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1 Cited Publications
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RU-301 is a pan TAM inhibitor that blocks Gas6-induced TAM activation and tumorigenicity. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis .
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1 Cited Publications
Cat. No.: HY-P700724
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709
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1 Cited Publications
Cat. No.: HY-P75174A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AXLLG; AXSFAXL receptor tyrosine kinase ligand; GAS-6
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RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth .
Cat. No.: HY-P99161
CAS No.: 2226775-26-2
Synonyms: BGB149
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Cat. No.: HY-177332
CAS No.: 1783825-18-2
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SLC-391 is an orally active AXL kinase inhibitor with an IC50 of 9.6 nM against AXL kinase. SLC-391 inhibits Gas6-induced AXL-dependent phosphorylation of Akt. SLC-391 inhibits SARS-CoV-2 infection, entry and replication in cells. SLC-391 suppresses cancer cell proliferation. SLC-391 inhibits tumor growth in mouse solid tumor xenograft models. SLC-391 can be used for the research of COVID-19, influenza virus infection, triple-negative breast cancer, chronic myeloid leukemia and non-small cell lung cancer .
Cat. No.: HY-RS16715
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Gas6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gas6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05285
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GAS6 Human Pre-designed siRNA Set A contains three designed siRNAs for GAS6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23150
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Gas6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gas6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-149092
CAS No.: 2097497-16-8
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Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models .
Cat. No.: HY-152075
CAS No.: 2947506-65-0
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AXL-IN-14 is a potent and orally active AXL inhibitor with an IC50 value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity .
Cat. No.: HY-P992231
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Cat. No.: HY-P700723
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709
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Source:
Cat. No.: HY-P704624
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709
Cat. No.: HY-P704625
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GAS-6; AXLLG; GAS6; DKFZp666G247; FLJ34709
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
