1182129-77-6
1182129-77-6
Chemical Structure
RU-302
- CAS No.: 1182129-77-6
- Formula:C24H24F3N3O2S
- Molecular Weight:475.53
IUPAC Name: (2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)phenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone
InChIKey: IZHRNXCFYZERFF-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1SCC2=C(C)ON=C2C)N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3
Biological Activity: RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1].
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RU-302 | 98.72% | RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth. | ||||||||||||||||||||
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References
Keywords
