4 Results for "

HBMECs

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "HBMECs" in MCE Product Catalog:

1
β-Estradiol 17-acetate
β-Estradiol 17-acetate
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1 Cited Publications
Cat. No.: HY-B0708
CAS No.: 1743-60-8
Synonyms: 1,3,5(10)-Estratriene-3,17β-diol 17-acetate
Category:  

Monophenols Animals Phenols Disease Research Fields Endocrinology Steroids

Target:  

Estrogen Receptor/ERR

β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice .
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DEL-S1
DEL-S1
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Cat. No.: HY-175200
Target:  

Slit Proteins

Research Areas:  

Neurological Disease Cancer

DEL-S1 is a SLIT2 binder. DEL-S1 significantly inhibits the formation of the SLIT2/ROBO1 complex by inducing conformational rearrangement, and further suppresses its function, with an IC50 of 68.8 μM. DEL-S1 can be used in studies of neurodevelopment, immunomodulation, and cancers such as glioblastoma .
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8α-Tigloyloxyhirsutinolide 13-O-acetate
8α-Tigloyloxyhirsutinolide 13-O-acetate
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Cat. No.: HY-138071
CAS No.: 83182-58-5
Synonyms: 8αTGH
Category:  

Terpenoids Sesquiterpenes Plants Compositae Dalbergia frutescens (Vell.) Britton

Target:  

STAT Pyroptosis Apoptosis Reactive Oxygen Species (ROS) c-Myc Bcl-2 Family TrxR

8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo .
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AM9928
AM9928
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Cat. No.: HY-182639
CAS No.: 1869033-49-7
Target:  

Exosomes MAGL Interleukin Related VEGFR

Research Areas:  

Cancer

AM9928 is a monoacylglycerol lipase (MAGL) inhibitor with IC50 and Ki values of 8.9 nM and 7.3 nM, respectively. AM9928 blocks the adhesion and migration of triple-negative breast cancer (TNBC) cells, and inhibits the secretion of IL-6, IL-8 and VEGF-A by TNBC cells. AM9928 suppresses the activation of human brain microvascular endothelial cells (HBMECs) induced by TNBC-derived exosomes, and reduces the secretion of IL-8 and VEGF-A by HBMECs. AM9928 attenuates changes in blood-brain barrier permeability, inhibits tumor growth in the mammary fat pad, and reduces brain colonization of TNBC. AM9928 can be used in studies related to triple-negative breast cancer .
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