13 Results for "

HT22+cell

" in MedChemExpress (MCE) Product Catalog:
Products (13)

13 Results for "HT22+cell" in MCE Product Catalog:

2
CMS-121
CMS-121
0 Images
2 Cited Publications
Cat. No.: HY-135981
CAS No.: 1353224-53-9
Purity:  98.30%
Target:  

Acetyl-CoA Carboxylase

연구분야:  

Neurological Disease Inflammation/Immunology

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .
JGB-1-155
JGB-1-155
0 Images
Cat. No.: HY-163280
CAS No.: 3011930-28-9
Target:  

NAMPT

연구분야:  

Neurological Disease

JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD + in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells .
Sanggenol O
Sanggenol O
0 Images
Cat. No.: HY-N9966
CAS No.: 426211-27-0
Category:  

Flavonoids Flavonones Morus alba L. Plants Moraceae

Target:  

Others

Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC50s more than 80 μM in HepG2 and HT22 cells .
P2Y1 antagonist 4
P2Y1 antagonist 4
0 Images
Cat. No.: HY-175675
CAS No.: 3104888-50-5
Target:  

P2Y Receptor Keap1-Nrf2

연구분야:  

Cardiovascular Disease Neurological Disease

P2Y1 antagonist 4 is a selective P2Y1 receptor antagonist with excellent blood-brain barrier (BBB) penetration. P2Y1 antagonist 4 inhibits P2Y1 receptor-mediated cytosolic Ca 2+ increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. P2Y1 antagonist 4 significantly upregulates the level of nuclear Nrf2 protein in H2O2-treated HT22 cells. P2Y1 antagonist 4 reduces myocardial infarct size in a mouse acute myocardial infarction (MI) model. P2Y1 antagonist 4 can be used for the study of ischemic stroke and myocardial infarction .
HBV-IN-44
HBV-IN-44
0 Images
Cat. No.: HY-161327
Target:  

HBV

연구분야:  

Infection

HBV-IN-44 (Compound (S)-2a) is a HBV inhibitor with a IC50 value of 23 nM for HbsAg. HBV-IN-44 is less toxic to the neurite growth of HT22 cells and DRG neurons in vitro .
Juncuenin D
Juncuenin D
0 Images
Cat. No.: HY-N8464
CAS No.: 1161681-24-8
Category:  

Natural Products Juncaceae Plants Juncus acutus L.

Target:  

Bacterial

Juncuenin D induces caspase-3-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus .
4-O-Methylbutein
4-O-Methylbutein
0 Images
Cat. No.: HY-N8412
CAS No.: 13323-67-6
Category:  

Labiatae Anthyllis vulneraria L. Phenols Polyphenols Plants

Target:  

Others

4-O-Methylbutein is a phenolic glucoside that can be isolated from Elsholtzia ciliata.4-O-Methylbutein exhibits neuroprotective effects against glutamate-induced HT22 cell death with an EC50 of 35.2 μM .
2-(Isopentylamino)naphthalene-1,4-dione
2-(Isopentylamino)naphthalene-1,4-dione
0 Images
Cat. No.: HY-139382
CAS No.: 1607447-79-9
Target:  

Cytochrome P450

연구분야:  

Neurological Disease

2-(Isopentylamino)naphthalene-1,4-dione (compound 3d), a Vitamin K (HY-B2172) analogue, shows protection in Pentylenetetrazole (PTZ)-induced seizure model. 2-(Isopentylamino)naphthalene-1,4-dione significantly increases ATP levels in zebrafish as well as HT-22 cells. 2-(Isopentylamino)naphthalene-1,4-dione shows excellent permeability into the brain .
2,5-Dihydroxy-4-methoxyacetophenone
2,5-Dihydroxy-4-methoxyacetophenone
0 Images
Cat. No.: HY-W670700
CAS No.: 22089-12-9
Category:  

Asclepiadaceae Phenols Polyphenols Cynanchum paniculatum (Bunge) Kitagawa Plants

Target:  

MMP

2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line . 2,5-Dihydroxy-4-methoxyacetophenone significantly inhibites MMP-13 expression in SW1353 cells, and have the potential for alleviating cartilage degradation .
MAO-B-IN-49
MAO-B-IN-49
0 Images
Cat. No.: HY-178352
CAS No.: 3098883-91-8
Target:  

Monoamine Oxidase Reactive Oxygen Species (ROS)

연구분야:  

Neurological Disease Inflammation/Immunology

MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9 μM). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750)-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD .
NEPP11
NEPP11
0 Images
Cat. No.: HY-180327
CAS No.: 313051-12-6
Target:  

Drug Derivative Apoptosis Keap1-Nrf2 Raf MEK ERK

연구분야:  

Neurological Disease Inflammation/Immunology

NEPP11 is a cyclopentenone prostaglandin analogue. NEPP11 can inhibit glutamate-induced HT22 cell death in mouse hippocampus and prevent manganese-induced apoptosis in PC12 cells. NEPP11 can activate Nrf2 and maintain MEK1/2 and ERK1/2 activity by inhibiting c-Raf downregulation. NEPP11 exerts a neuroprotective effect in a mouse model of focal cerebral ischemia caused by permanent middle cerebral artery occlusion .
DYRK2-IN-2
DYRK2-IN-2
0 Images
Cat. No.: HY-402805
CAS No.: 2416195-65-6
Target:  

DYRK CDK Tau Protein

연구분야:  

Cancer

DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC50 value being 40.3 nM. The inhibitory activity of DYRK2-IN-2 on DYRK1A (IC50 = 1842 nM), DYRK1B (IC50 = 1335 nM), DYRK4 (IC50 = 1931 nM), DYRK3 (IC50 = 112 nM), and CLKs (IC50 = 540-6496 NM) is relatively low. DYRK2-IN-2 inhibits the phosphorylation of Tau protein at Thr212 and shows moderate cytotoxicity in HT22 cells. DYRK2-IN-2 can be used in cancer research .
PICK1 PDZ-IN-1
PICK1 PDZ-IN-1
0 Images
Cat. No.: HY-180197
Target:  

PKC iGluR Reactive Oxygen Species (ROS)

연구분야:  

Cardiovascular Disease Neurological Disease

PICK1 PDZ-IN-1 (Compound 6b) is a selective and brain-penetrant protein interacting with C kinase 1 (PICK1) PDZ domain inhibitor with a Ki of 27.73 μM. PICK1 PDZ-IN-1 can competitively inhibit the interaction between PICK1 and the GluA2 subunit of AMPA receptors. PICK1 PDZ-IN-1 can increase the survival rate of HT22 cells and primary cortical neuron cells induced by glutamate and inhibit ROS production. PICK1 PDZ-IN-1 exhibits neuroprotective effect and reduces the area of cerebral infarction. PICK1 PDZ-IN-1 can be used for the research of ischemic stroke .
  • 1
Assay Types