3011930-28-9
Chemical Structure
JGB-1-155
- CAS No.: 3011930-28-9
- Formula:C26H38N2O3
- Molecular Weight:426.59
InChIKey: XUAJYFDMEHVNTH-UHFFFAOYSA-N
SMILES: O=C(N(CCC1(C(C)C)CCOC(C)(C1)C)CC2=CC=C(N(C)C)C=C2)C3=CC=CO3
Biological Activity: JGB-1-155 is a nicotinamide phosphoribosyltransferase (NAMPT) activator and also a reactive oxygen species (ROS) inhibitor. JGB-1-155 binds to NAMPT, thereby enhancing its catalytic activity and increasing intracellular NAD+ levels. JGB-1-155 alleviates the elevation of ROS levels induced by various types of damage. JGB-1-155 can be used in research related to neurodegenerative diseases[1][2].
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JGB-1-155 | JGB-1-155 is a nicotinamide phosphoribosyltransferase (NAMPT) activator and also a reactive oxygen species (ROS) inhibitor. JGB-1-155 binds to NAMPT, thereby enhancing its catalytic activity and increasing intracellular NAD+ levels. JGB-1-155 alleviates the elevation of ROS levels induced by various types of damage. JGB-1-155 can be used in research related to neurodegenerative diseases. | |||||||||||||||||||||
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- [1]. Gordon-Blake J, et al. Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS medicinal chemistry letters. 2024 Feb 08;15(2):205-214. [Content Brief]
- [2]. Gordon-Blake J. Development of NAMPT Positive Allosteric Modulators as Potential Alzheimer’s Disease Therapeutics. Chicago: University of Illinois Chicago, 2022.
Keywords
