22089-12-9
Chemical Structure
2,5-Dihydroxy-4-methoxyacetophenone
- CAS No.: 22089-12-9
- Formula:C9H10O4
- Molecular Weight:182.17
IUPAC Name: 1-(2,5-dihydroxy-4-methoxyphenyl)ethan-1-one
InChIKey: TXBDGLVJCSOBLF-UHFFFAOYSA-N
SMILES: O=C(C)C1=C(O)C=C(OC)C(O)=C1
Biological Activity: 2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line[1]. 2,5-Dihydroxy-4-methoxyacetophenone significantly inhibites MMP-13 expression in SW1353 cells, and have the potential for alleviating cartilage degradation[2].
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2,5-Dihydroxy-4-methoxyacetophenone | 98.55% | 2,5-Dihydroxy-4-methoxyacetophenone (compounds 3) can be isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa. 2,5-Dihydroxy-4-methoxyacetophenone inhibits glutamate-induced cytotoxicity in hippocampal HT22 cell line. 2,5-Dihydroxy-4-methoxyacetophenone significantly inhibites MMP-13 expression in SW1353 cells, and have the potential for alleviating cartilage degradation. | ||||||||||||||||||||
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- [1]. Jin Bae Weon, et al. Neuroprotective compounds isolated from Cynanchum paniculatum. Arch Pharm Res. 2012, 35, 4. [Content Brief]
- [2]. Lee, Ju-Hee, et al. Viscum Album and Its Constituents Downregulate MMP-13 Expression in Chondrocytes and Protect Cartilage Degradation. Natural Product Sciences, vol. 27, no. 3. The Korean Society of Pharmacognosy, pp. 151–160, 30-Sep-2021.
Keywords
