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Results for "

IL-36R

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (6) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (5)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99396

Spesolimab BI 655130	Interleukin Related	Inflammation/Immunology
Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against *IL-36R*. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways .

HY-P99659

Imsidolimab ANB 019	Interleukin Related	Inflammation/Immunology
Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti-IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases .

HY-RS06726

IL1RL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL1RL2 Human Pre-designed siRNA Set A contains three designed siRNAs for IL1RL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL1RL2 Human Pre-designed siRNA Set A IL1RL2 Human Pre-designed siRNA Set A

HY-P991281

REGN6490	Interleukin Related	Inflammation/Immunology
REGN6490 is a humanized monoclonal anti-IL1RL2/IL-36R antibody. REGN6490 can be used in research related to pustular psoriasis .

HY-172660

36R-D481	Interleukin Related	Inflammation/Immunology
36R-D481 is a competitive and orthosteric antagonist of *IL-36R, effectively inhibiting IL-36 signaling. 36R-D481 can inhibit IL-36α* and IL-36γ but not IL-36β induced IL-8 release .

HY-P992384

IMG-008	Interleukin Related	Inflammation/Immunology
IMG-008 is a fully human antagonistic antibody targeting *IL-36R, acting as a high-affinity IL-36R* inhibitor (K_d = 6.23 pM). IMG-008 competitively blocks the pro-inflammatory signaling pathway mediated by human IL-36R, inhibiting receptor activation and the production of inflammatory cytokines. IMG-008 suppresses Imiquimod (HY-B0180)-induced skin inflammation in humanized mice, and Fc modification increases its serum exposure and prolongs its half-life. IMG-008 can be used in studies related to IL-36R-mediated inflammatory diseases such as psoriasis .

HY-P991468

IMM20324	Interleukin Related	Cancer
IMM20324 is a human monoclonal antibody (mAb) targeting IL38. IMM20324 inhibits the interaction of IL-38 with human IL1RAPL1-Fc and human IL-36R-Fc with IC₅₀ values of 1.267 nM and 1.4667 nM, respectively. IMM20324 has antitumor activity in the B16.F10 syngeneic mouse model. IMM20324 can be used in antitumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99396

Spesolimab BI 655130	Interleukin Related	Inflammation/Immunology
Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against *IL-36R*. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways .

HY-P99659

Imsidolimab ANB 019	Interleukin Related	Inflammation/Immunology
Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti-IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases .

HY-P991281

REGN6490	Interleukin Related	Inflammation/Immunology
REGN6490 is a humanized monoclonal anti-IL1RL2/IL-36R antibody. REGN6490 can be used in research related to pustular psoriasis .

HY-P992384

IMG-008	Interleukin Related	Inflammation/Immunology
IMG-008 is a fully human antagonistic antibody targeting *IL-36R, acting as a high-affinity IL-36R* inhibitor (K_d = 6.23 pM). IMG-008 competitively blocks the pro-inflammatory signaling pathway mediated by human IL-36R, inhibiting receptor activation and the production of inflammatory cytokines. IMG-008 suppresses Imiquimod (HY-B0180)-induced skin inflammation in humanized mice, and Fc modification increases its serum exposure and prolongs its half-life. IMG-008 can be used in studies related to IL-36R-mediated inflammatory diseases such as psoriasis .

HY-P991468

IMM20324	Interleukin Related	Cancer
IMM20324 is a human monoclonal antibody (mAb) targeting IL38. IMM20324 inhibits the interaction of IL-38 with human IL1RAPL1-Fc and human IL-36R-Fc with IC₅₀ values of 1.267 nM and 1.4667 nM, respectively. IMM20324 has antitumor activity in the B16.F10 syngeneic mouse model. IMM20324 can be used in antitumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

Species:	Human (5) Mouse (1) Cynomolgus (1)
Tag:	His (6) Avi (2) Fc (1)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78462

	IL-1RL2 Protein, Human (HEK293, His-Avi) IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R	Human	HEK293
	IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78145

	IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi) IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R	Human	HEK293
	IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P70603

	IL-1RL2 Protein, Human (HEK293, His) Interleukin-1 receptor-like 2; IL1RL2; IL-36 receptor; IL-36R; IL-1Rrp2; IL1R-rp2;	Human	HEK293
	IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (HEK293, His) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70625

	IL-1RL2 Protein, Human (HEK293, Fc) Interleukin-1 receptor-like 2; IL1RL2; IL-36 receptor; IL-36R; IL-1Rrp2; IL1R-rp2;	Human	HEK293
	IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (HEK293, Fc) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77698

	IL-1 Rrp2/IL-1 R6 Protein, Cynomolgus (HEK293, His) IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R	Cynomolgus	HEK293
	L-36R is a member of the IL-1 receptor family that contains six receptor proteins that form four signaling complexes: IL-1RI, IL-18R, IL-33R, and IL-36R, and two decoy receptors and two negative regulators. IL-36R is a heterodimer that consists of a receptor subunit named IL-1Rrp2 (IL-1RL2) and a co-receptor subunit Interleukin-1 receptor accessory protein, IL-1RAcP. The receptor can recognize three different agonists, IL-36α, IL-36β, and IL-36γ (also known as IL-1F6, IL-1F8, and IL-1F9), to induce the expression of inflammatory cytokines. IL-1 Rrp2/IL-1 R6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-1 Rrp2/IL-1 R6 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70748

	IL-1RL2 Protein, Mouse (A158V, HEK293, His) Interleukin-1 receptor-like 2; IL1RL2; IL-36 receptor; IL-36R; IL-1Rrp2; IL1R-rp2	Mouse	HEK293
	The IL-1RL2 protein functions as a receptor for interleukin 36 (IL36A, IL36B, and IL36G) and upon binding forms a complex with the coreceptor IL1RAP. This IL-36 receptor complex plays a key role in activating NF-κ-B, MAPK, and other signaling pathways. IL-1RL2 Protein, Mouse (A158V, HEK293, His) is the recombinant mouse-derived IL-1RL2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78547

	IL-1RL2 Protein, Human (C154S, C262S, HEK293, His) IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R	Human	HEK293
	IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (C154S, C262S, HEK293, His) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-His labeled tag and C154S, C262S mutation.

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IL1RL2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL1RL2 Human Pre-designed siRNA Set A contains three designed siRNAs for IL1RL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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