Spesolimab
Based on 1 Customer Validation
Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against IL-36R. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 2097104-58-8
- Molecular Weight:145.5 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 (L234A/L235A) kappa
Human
IL-1RL2/IL-36R
The Ka (M-1s-1) of spesolimab is 1.36×106, Kd (s-1) is 3.28×10-5, KD (pM) is 24, the IC90 is 0.9 nM in the NCI/ADR-RES ovarian epithelial cell line and the IC90 is 1.9 nM in primary human dermal fibroblasts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized IL-1RL2 Protein, Human (HEK293, His, HY-P70603) can bind Spesolimab. The EC50 for this effect is 6.924 ng/mL.
Chemical Information
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CAS No. 2097104-58-8
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Appearance Liquid
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Molecular Weight 145.5 kDa
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Color Colorless to light yellow
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SMILES
[Spesolimab]
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Synonyms
BI 655130
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Mrowietz U, et al. Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study. Dermatol Ther (Heidelb). 2021 Apr;11(2):571-585. [Content Brief]
[3]. Jennifer Ahlberg, et al. Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5). MAbs. 2019 Jul;11(5):956-964. [Content Brief]
[4]. Rajkumar Ganesan, et al. Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.MAbs. 2017 Oct;9(7):1143-1154. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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