3 Results for "

Isopsoralen

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Isopsoralen" in MCE Product Catalog:

11
Angelicin
Angelicin
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11 Cited Publications
Cat. No.: HY-N0763
CAS No.: 523-50-2
Synonyms: Isopsoralen
Category:  

Leguminosae Coumarins Psoralea corylifolia L. Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.
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Isopsoralenoside
Isopsoralenoside
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Cat. No.: HY-N7504
CAS No.: 905954-18-9
Category:  

Infection Leguminosae Ketones, Aldehydes, Acids Metabolic Disease Psoralea corylifolia L. Plants Disease Research Fields

Target:  

Bacterial Reactive Oxygen Species (ROS)

Isopsoralenoside is a benzofuran glycoside and coumarin-derived compound. Isopsoralenoside exists in the dried mature fruits of Psoralea corylifolia L., and acts as a metabolite precursor, toxicant and inducer, with estrogen-like, osteoblast proliferation-promoting, anti-tumor and antibacterial activities. Isopsoralenoside can be deglycosylated by intestinal flora to form isopsoralen. Isopsoralenoside induces oocyte death in zebrafish, activates oxidative stress and cell death-related pathways in zebrafish follicles, and is the main effector substance responsible for the reproductive toxicity induced by Fructus Psoraleae. Isopsoralenoside can be used in studies related to reproductive toxicity (ovarian dysfunction, follicular atresia, impaired fertility) .
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Angelicin (Standard)
Angelicin (Standard)
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Cat. No.: HY-N0763R
CAS No.: 523-50-2
Synonyms: Isopsoralen (Standard)
Category:  

Leguminosae Coumarins Psoralea corylifolia L. Phenylpropanoids Plants

Target:  

Reference Standards Apoptosis Virus Protease

Angelicin (Standard) is the analytical standard of Angelicin. This product is intended for research and analytical applications. Angelicin is a natural tricyclic aromatic hydrocarbon compound that is structurally related to psoralen and has anti-cancer, anti-inflammatory, anti-viral and other activities. Cytotoxic, IC50: 49.56 μM; inhibits MHV-68, IC50: 5.39 μg/ml (28.95 μM).
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