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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
KU812
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "KU812" in MCE Product Catalog:
Synonyms: TAS-205 free base
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Pizuglanstat (Compound 3; TAS-205 free base) is an orally active prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat inhibits the synthesis of PGD2. Pizuglanstat improves experimental allergic rhinitis. Pizuglanstat can be used in the study of muscle regenerative diseases such as muscular dystrophy .
Cat. No.: HY-109134A
CAS No.: 1584160-52-0
Synonyms: TAS-205
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Pizuglanstat hydrate (Compound 3; TAS-205) is an orally active prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat hydrate inhibits the synthesis of PGD2. Pizuglanstat hydrate improves experimental allergic rhinitis. Pizuglanstat hydrate can be used in the study of muscle regenerative diseases such as muscular dystrophy .
Cat. No.: HY-170837
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance .
Cat. No.: HY-157577
CAS No.: 2761281-51-8
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PROTAC (H-PGDS)-8 is an H-PGDS PROTAC inhibitor with a IC50 of 0.14 μM. PROTAC (H-PGDS)-8 binds to H-PGDS and inhibits its enzymatic activity. PROTAC (H-PGDS)-8 inhibits the production of PGD2 in cancer cells. PROTAC (H-PGDS)-8 can be used for the research of Duchenne muscular dystrophy .
Cat. No.: HY-109134R
CAS No.: 1244967-98-3
Synonyms: TAS-205 free base (Standard)
Research Areas:
Pizuglanstat (Standard) is the analytical standard of Pizuglanstat (HY-109134). This product is intended for research and analytical applications. Pizuglanstat (Compound 3; TAS-205 free base) is an orally active prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat inhibits the synthesis of PGD2. Pizuglanstat improves experimental allergic rhinitis. Pizuglanstat can be used in the study of muscle regenerative diseases such as muscular dystrophy .
Cat. No.: HY-184486
CAS No.: 16781-09-2
Synonyms: 1-Amino-8-naphthol-2,4-disulfonic acid
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ANDS (1-Amino-8-naphthol-2,4-disulfonic acid) is an orally active inhibitor of CaMKP (IC50 = 6.4 μM; Ki = 3.6 μM) and CaMKP‑N (IC50 = 6.6 μM) . ANDS binds unacetylated p53 and restores p53 activity by disrupting ANP32B-p53 interaction. ANDS inhibits chronic myeloid leukemia (CML) cell proliferation, impairs leukemic stem cells (LSC) function and prolongs survival in CML mouse model while sparing normal progenitor cells. ANDS can be used to study the eradication of LSCs and the overcoming of tyrosine kinase inhibitor (TKI) resistance in CML . ANDS can be used to study breast cancer .
Cat. No.: HY-N11725
CAS No.: 128129-56-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
