16781-09-2
Chemical Structure
ANDS
Synonym(s): 1-Amino-8-naphthol-2,4-disulfonic acid
- CAS No.: 16781-09-2
- Formula:C10H7NNa2O7S2
- Molecular Weight:363.27
InChIKey: XZGHMYIWMXYELB-UHFFFAOYSA-L
SMILES: NC1=C(C=C(C2=C1C(O)=CC=C2)S(=O)(O[Na])=O)S(=O)(O[Na])=O
Biological Activity: ANDS (1-Amino-8-naphthol-2,4-disulfonic acid) is an orally active inhibitor of CaMKP (IC50 = 6.4 μM; Ki = 3.6 μM) and CaMKP‑N (IC50 = 6.6 μM)[2]. ANDS binds unacetylated p53 and restores p53 activity by disrupting ANP32B-p53 interaction. ANDS inhibits chronic myeloid leukemia (CML) cell proliferation, impairs leukemic stem cells (LSC) function and prolongs survival in CML mouse model while sparing normal progenitor cells. ANDS can be used to study the eradication of LSCs and the overcoming of tyrosine kinase inhibitor (TKI) resistance in CML[1]. ANDS can be used to study breast cancer[3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
ANDS | ANDS (1-Amino-8-naphthol-2,4-disulfonic acid) is an orally active inhibitor of CaMKP (IC50 = 6.4 μM; Ki = 3.6 μM) and CaMKP‑N (IC50 = 6.6 μM). ANDS binds unacetylated p53 and restores p53 activity by disrupting ANP32B-p53 interaction. ANDS inhibits chronic myeloid leukemia (CML) cell proliferation, impairs leukemic stem cells (LSC) function and prolongs survival in CML mouse model while sparing normal progenitor cells. ANDS can be used to study the eradication of LSCs and the overcoming of tyrosine kinase inhibitor (TKI) resistance in CML. ANDS can be used to study breast cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Wei YS, et al. The disulfonic acid ANDS disrupts ANP32B-p53 interaction to suppress chronic myeloid leukemia. Nat Commun. 2026 Jun 10. [Content Brief]
- [2]. Sueyoshi N, et al. Inhibitors of the Ca(2+)/calmodulin-dependent protein kinase phosphatase family (CaMKP and CaMKP-N). Biochem Biophys Res Commun. 2007 Nov 23;363(3):715-21. [Content Brief]
- [3]. Akizuki K, et al. CaMK phosphatase (CaMKP/POPX2/PPM1F) inhibitors suppress the migration of human breast cancer MDA-MB-231 cells with loss of polarized morphology. Biochem Biophys Res Commun. 2023 Jan 8;639:1-8. [Content Brief]
Keywords
