1. Protein Tyrosine Kinase/RTK
    MAPK/ERK Pathway
  2. Bcr-Abl
    Src
    p38 MAPK
  3. CHMFL-ABL-053

CHMFL-ABL-053 

Cat. No.: HY-101268
Handling Instructions

CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively.

For research use only. We do not sell to patients.

CHMFL-ABL-053 Chemical Structure

CHMFL-ABL-053 Chemical Structure

CAS No. : 1808287-83-3

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Description

CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively[1].

IC50 & Target

p38

62 nM (IC50)

Abl

70 nM (IC50)

SRC

90 nM (IC50)

In Vitro

CHMFL-ABL-053 (Compound 18a) inhibits the proliferation of CML cell lines with GI50 of 14, 25 and 16 nM against K562, KU812 and MEG-01, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CHMFL-ABL-053 (Compound 18a) (50 mg/kg/day) almost completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

549.55

Formula

C28H26F3N7O2

CAS No.
SMILES

O=C(C1=CN=C(NC2=CC=C(C)C(N)=C2)N=C1NC)NC3=CC(NC(C4=CC=CC(C(F)(F)F)=C4)=O)=CC=C3C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
CHMFL-ABL-053
Cat. No.:
HY-101268
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