1 Result for "

L-His-BPA

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "L-His-BPA" in MCE Product Catalog:

Cat. No.: HY-183596
CAS No.: 2941355-21-9
Target:  

Drug Intermediate

Research Areas:  

Cancer

L-His-BPA is a prodrug of L-p-Boronophenylalanine (L-BPA) (HY-W087830), formed by the peptide bond linkage of L-histidine (L-His) (HY-N0832) and L-BPA. L-His-BPA is rapidly cleaved by endogenous proteases to de novo release L-BPA in the systemic circulation. When used in combination with neutron irradiation, L-His-BPA induces complete and durable tumor regression, elicits cancer vaccine responses, and produces abscopal inhibitory effects on unirradiated distant tumors. L-His-BPA can be used in studies of boron neutron capture therapy (BNCT) for relapsed/advanced solid tumors .
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