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Lobeline

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Dopamine Transporter (4) nAChR (4) Reference Standards (1)
By Research Areas:	Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-B0979

Lobeline hydrochloride 1 Publications Verification α-Lobeline hydrochloride; L-Lobeline hydrochloride	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-W016750

Pentane-1,5-diamine dihydrochloride	Biochemical Assay Reagents	Others
Pentane-1,5-diamine dihydrochloride is a putrescine. Pentane-1,5-diamine dihydrochloride can be incorporated into lobeline, but it is not a conventional intermediate in the lysine-to-lobeline synthesis process .

HY-B1423

*Lobeline* α-Lobeline; L-Lobeline	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation .

HY-N8505

Lobelanine 1 Publications Verification 8,10-Diphenyllobelidione	Others	Others
Lobelanine (8,10-Diphenyllobelidione) is a chemical precursor for the biosynthesis of Lobeline. Lobeline is a partial nicotinic agonist and is used as a smoking cessation agent .

HY-B0979R

Lobeline hydrochloride (Standard) α-Lobeline hydrochloride (Standard); L-Lobeline hydrochloride (Standard)	Reference Standards nAChR Dopamine Transporter	Neurological Disease
Lobeline (hydrochloride) (Standard) is the analytical standard of Lobeline (hydrochloride). This product is intended for research and analytical applications. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-128420

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation .

Lobeline hydrochloride 1 Publications Verification α-Lobeline hydrochloride; L-Lobeline hydrochloride	Alkaloids Campanulaceae Pyridine Alkaloids Plants Lobelia chinensis Lour. Source Classification	nAChR Dopamine Transporter
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

Pentane-1,5-diamine dihydrochloride	Structural Classification Productos naturales Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Biochemical Assay Reagents
Pentane-1,5-diamine dihydrochloride is a putrescine. Pentane-1,5-diamine dihydrochloride can be incorporated into lobeline, but it is not a conventional intermediate in the lysine-to-lobeline synthesis process .

*Lobeline* α-Lobeline; L-Lobeline	Alkaloids Other Alkaloids Campanulaceae Plants Lobelia chinensis Lour. Source Classification	nAChR Dopamine Transporter
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation .

Lobelanine 1 Publications Verification 8,10-Diphenyllobelidione	Alkaloids Piperidine Alkaloids Classification of Application Fields Other Diseases Campanulaceae Plants Disease Research Fields Lobelia chinensis Lour. Source Classification	Others
Lobelanine (8,10-Diphenyllobelidione) is a chemical precursor for the biosynthesis of Lobeline. Lobeline is a partial nicotinic agonist and is used as a smoking cessation agent .

Lobeline hydrochloride (Standard) α-Lobeline hydrochloride (Standard); L-Lobeline hydrochloride (Standard)	Alkaloids Structural Classification Campanulaceae Pyridine Alkaloids Plants Lobelia chinensis Lour. Source Classification	Reference Standards nAChR Dopamine Transporter
Lobeline (hydrochloride) (Standard) is the analytical standard of Lobeline (hydrochloride). This product is intended for research and analytical applications. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	Alkaloids other families Pyridine Alkaloids Plants Endogenous metabolite Source Classification	nAChR Dopamine Transporter
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Lobeline

Inhibitors & Agonists

NaturalProducts

Natural
Products