Lobeline sulfate
Based on 1 publication(s) in Google Scholar
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation.
For research use only. We do not sell to patients.
- CAS No.: 134-64-5
- Formula: C44H56N2O8S
- Molecular Weight:772.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lobeline sulfate
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Biological Activity
IC50: endogenous metabolite[1]
Lobeline (3 mg/kg; s.c.; 7 times during 7 sessions) sulfate specifically decreases responding for d-Methamphetamine in a noncompetitive manner, and increases tolerance development[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (200-250 g)[3]
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Dosage:0.3 mg/kg, 1.0 mg/kg, and 3.0 mg/kg for acute administration; 3 mg/kg for chronic administration
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Administration:Subcutaneous injection; 15 min prior to measurement, or every 15 min for 7 sessions; separated by 2 intervening maintenance days of d-methamphetamine (0.05 mg/kg/infusion) self-administration
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Result:Decreased d-methamphetamine Self-Administration.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 134-64-5
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Molecular Weight 772.99
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Formula C44H56N2O8S
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SMILES
CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.CN4[C@@H](CC(C5=CC=CC=C5)=O)CCC[C@H]4C[C@H](O)C6=CC=CC=C6.O=S(O)(O)=O
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Synonyms
α-Lobeline sulfate; L-Lobeline sulfate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280(3):1432-44. [Content Brief]
[3]. Monzurul Amin Roni, et al. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017 Jun:61:63-70. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lobeline sulfate Related Classifications
HY-128420 Related Classifications
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