134-64-5
Chemical Structure
Lobeline sulfate
Synonym(s): α-Lobeline sulfate; L-Lobeline sulfate
- CAS No.: 134-64-5
- Formula:C44H56N2O8S
- Molecular Weight:772.99
IUPAC Name: 2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one hemisulfate
InChIKey: GRZMOSSVIPFGFF-GNJLJDPWSA-N
SMILES: CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3.CN4[C@@H](CC(C5=CC=CC=C5)=O)CCC[C@H]4C[C@H](O)C6=CC=CC=C6.O=S(O)(O)=O
Biological Activity: Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation[1][2].
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Lobeline sulfate | Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation. | |||||||||||||||||||||
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- [1]. Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280(3):1432-44. [Content Brief]
- [2]. https://mayoclinic.pure.elsevier.com/en/publications/a-smoking-cessation-trial-with-lobeline-sulfate-a-pilot-st
Keywords
