90-69-7
90-69-7
Chemical Structure
Lobeline
Synonym(s): α-Lobeline; L-Lobeline
- CAS. Nr.: 90-69-7
- Formula:C22H27NO2
- Molecular Weight:337.46
IUPAC Name: 2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one
InChIKey: MXYUKLILVYORSK-HBMCJLEFSA-N
SMILES: CN1[C@@H](CC(C2=CC=CC=C2)=O)CCC[C@H]1C[C@H](O)C3=CC=CC=C3
Biological Activity: Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation[1][2].
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Lobeline | Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation. | |||||||||||||||||||||
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References
- [1]. Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar;280(3):1432-44. [Content Brief]
- [2]. Monzurul Amin Roni, et al. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017 Jun:61:63-70. [Content Brief]
Keywords
