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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
101 Results for "
MBP protein
" in MedChemExpress (MCE) Product Catalog:
Products (101)
101 Results for "MBP protein" in MCE Product Catalog:
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ZYF0033 is an orally active inhibitor of the hematopoietic progenitor cell kinase HPK1 with an IC50 of less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 promotes anti-cancer immune responses and reduces phosphorylation of SLP76 (serine 376). ZYF0033 inhibits tumor growth in the 4T-1 syngeneic mouse model and leads to increased intratumoral infiltration of DCs, NK cells, and CD107a +CD8 + T cells, but not T cells, PD-1 +CD8 + T cells, TIM-3 +CD8 + Infiltration of T cells and LAG3 +CD8 + T cells was reduced .
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REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM. REV7/REV3L-IN-1 binds directly to REV7 and inhibits its interaction with REV3L. REV7/REV3L-IN-1 inhibits interstrand crosslink repair in cells. REV7/REV3L-IN-1 chemosensitizes cancer cells to Cisplatin (HY-17394). REV7/REV3L-IN-1 can be used in cervical cancer research .
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PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
Cat. No.: HY-P10532
CAS No.: 121196-80-3
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Cat. No.: HY-P1048
CAS No.: 98474-59-0
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Cat. No.: HY-P3073
CAS No.: 106128-98-7
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Cat. No.: HY-P3724
CAS No.: 604803-17-0
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Cat. No.: HY-P3940
CAS No.: 138250-62-1
Cat. No.: HY-P3739
CAS No.: 136132-68-8
Cat. No.: HY-P1996
CAS No.: 178823-49-9
Synonyms: NBI-5788
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Cat. No.: HY-P10428
Cat. No.: HY-P1734
CAS No.: 125366-42-9
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Cat. No.: HY-P1289
CAS No.: 99026-78-5
Cat. No.: HY-P1289A
CAS No.: 99026-77-4
Cat. No.: HY-P10522
CAS No.: 106128-97-6
Cat. No.: HY-P10525
CAS No.: 167278-49-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
