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United States

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Cat. No.: HY-P10428

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E6AP-mimicking peptide

E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a K_i of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture.

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Formule: C₁₂₈H₁₉₃N₃₁O₂₉
Masse moléculaire:2630.09

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

E6AP-mimicking peptide Chemical Structure

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Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

Masse moléculaire 2630.09
Formule C₁₂₈H₁₉₃N₃₁O₂₉
Sequence

{9-fluorenyl acetamido}-Ile-Pro-Gln-Ser-Ala-Glu-Leu-Thr-Leu-Gln-Glu-Leu-{Dha}-Arg-Arg-Lys-Lys-Lys(1-anthracenyl acetamido)-NH2
Sequence Shortening

{9-fluorenyl acetamido}-IPQSAELTLQELL-{Dha}-RRKK-{Lys(1-anthracenyl acetamido)}-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xiyun Ye, et al. Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6. Chem Sci. 2023 Oct 25;14(44):12484-12497. [Content Brief]

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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