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MYPT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (2) Cadherin (1) JAK (1) ROCK (1) Small Interfering RNA (siRNA) (1) YAP (1)
By Research Areas:	Cancer (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156397

HTH-02-006	AMPK YAP	Cancer
HTH-02-006 is a NUAK2 inhibitor, with an IC₅₀ value of 126 nM. HTH-02-006 inhibits NUAK2-mediated signaling by reducing phosphorylation of its substrate *MYPT1* at S445 and downstream MLC. HTH-02-006 shows growth inhibitory efficacy in YAP-high cancer cells (HuCCT-1, SNU475). HTH-02-006 significantly suppresses YAP-induced hepatomegaly (reduced liver/body weight ratio) in TetO-YAP S127A transgenic mice and demonstrates significant anti-tumor efficacy in mice bearing HMVP2 prostate cancer allografts. HTH-02-006 can be used for the study of liver cancer and prostate cancer ^[1] .

HY-110335A

OXA-06	ROCK	Cancer
OXA-06 is a pharmacologic inhibitor of ROCK, possessing antitumor activity by impairing cell migration and MYPT1 phosphorylation in PANC-1 cells.

HY-182361

NUAK1-IN-3	AMPK JAK Cadherin	Cancer
NUAK1-IN-3 is a potent and selective *NUAK1* inhibitor with an IC₅₀ of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC₅₀ values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1, forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates *MYPT1* phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates Snail and N-cadherin, and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer ^[1].

HY-RS10978

PPP1R12A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PPP1R12A Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1R12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PPP1R12A Human Pre-designed siRNA Set A PPP1R12A Human Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77286

	DAPK3/ZIPK Protein, Human (sf9, GST) Death-associated protein kinase 3; DAP kinase 3; Dlk; MYPT1 kinase; ZIPK	Human	Sf9 insect cells
	The DAPK3/ZIPK protein is a multifunctional serine/threonine kinase that complexly regulates apoptosis, autophagy, transcription, translation, and actin cytoskeletal reorganization. Its key roles include coordinating apoptotic and autophagy signaling, influencing smooth muscle contraction, and regulating starvation-induced autophagy. DAPK3/ZIPK Protein, Human (sf9, GST) is the recombinant human-derived DAPK3/ZIPK protein, expressed by Sf9 insect cells , with N-GST labeled tag.

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Host:	Rabbit (5)
Reactivity:	Human (5) Rat (2) Mouse (2)
Application:	IHC-P (1) ICC/IF (1) WB (5) ELISA (1)
Isotype:	IgG (4) IgG/Kappa (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

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HY-P86347

	MYPT1 Antibody (YA6039) PPP1R12A; MBS; MYPT1; Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit	WB, IHC-P, ICC/IF, ELISA	Human
	MYPT1 Antibody (YA6039) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYPT1.

HY-P810682

	*Phospho-MYPT1* (Thr853) Antibody (YA9940)** PPP1R12A; MBS; MYPT1; Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit	WB	Human, Mouse, Rat
	Phospho-MYPT1 (Thr853) Antibody (YA9940) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-MYPT1 (Thr853).

HY-P810683

	*Phospho-MYPT1* (Thr696) Antibody (YA9941)** PPP1R12A; MBS; MYPT1; Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit	WB	Human, Mouse, Rat
	Phospho-MYPT1 (Thr696) Antibody (YA9941) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-MYPT1 (Thr696).

HY-P83574

	DAP kinase 3 Antibody (YA3319) DAPK3; ZIPK; Death-associated protein kinase 3; DAP kinase 3; DAP-like kinase; Dlk; MYPT1 kinase; Zipper-interacting protein kinase; ZIP-kinase	WB	Human
	DAP kinase 3 Antibody (YA3319) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAP kinase 3.

HY-P83574A

	DAP kinase 3 Antibody (YA3319)(PBS only) DAPK3; ZIPK; Death-associated protein kinase 3; DAP kinase 3; DAP-like kinase; Dlk; MYPT1 kinase; Zipper-interacting protein kinase; ZIP-kinase	WB	Human
	DAP kinase 3 Antibody (YA3319) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DAP kinase 3.

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Cat. No.	Product Name		Classification

HY-RS10978

PPP1R12A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PPP1R12A Human Pre-designed siRNA Set A contains three designed siRNAs for PPP1R12A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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