4 Results for "

Maackiain

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Maackiain" in MCE Product Catalog:

1
Maackiain
Maackiain
0 Images
1 Cited Publications
Cat. No.: HY-N0381
CAS No.: 19908-48-6
Synonyms: DL-​Maackiain
Category:  

Infection Natural Products other families Monophenols Phenols Plants Disease Research Fields

Target:  

Keap1-Nrf2 p38 MAPK NOD-like Receptor (NLR) NF-κB mTOR Monoamine Oxidase Nuclear Factor of activated T Cells (NFAT) PKC Apoptosis Pyroptosis Autophagy Dengue Virus

Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever 。
loading...
    loading...
View All Sizes
(-​)​-Maackiain
(-​)​-Maackiain
0 Images
Cat. No.: HY-N6051
CAS No.: 2035-15-6
Category:  

Infection Monophenols Leguminosae Terpenoids Phenols Diterpenoids Plants Sophora flavescens Aiton Disease Research Fields

Target:  

Fungal NOD-like Receptor (NLR) NF-κB

(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .
loading...
    loading...
View All Sizes
(+)-Maackiain
(+)-Maackiain
0 Images
Cat. No.: HY-N9795
CAS No.: 23513-53-3
Category:  

Monophenols Phenols Plants Styphnolobium japonicum (L.) Schott Fabaceae

Target:  

Others

(+)-Maackiain is a natural product .
loading...
    loading...
View All Sizes
(-)-Maackiain (Standard)
(-)-Maackiain (Standard)
0 Images
Cat. No.: HY-N6051R
CAS No.: 2035-15-6
Category:  

Monophenols Leguminosae Terpenoids Phenols Diterpenoids Plants Sophora flavescens Aiton

Target:  

Reference Standards Fungal NOD-like Receptor (NLR) NF-κB

(-​)​-Maackiain (Standard) is the analytical standard of (-​)​-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .
loading...
    loading...
View All Sizes
Assay Types