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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
NADPH-dependent reduction
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "NADPH-dependent reduction" in MCE Product Catalog:
Cat. No.: HY-W006230
CAS No.: 84-60-6
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Anthraflavic acid specifically inhibits the activity of cytochrome P-448 without affecting phenobarbital-induced cytochrome P-450 or NADPH-dependent cytochrome c reduction. Anthraflavic acid inhibits cytosolic metabolic pathways, blocks the microsomal and cytosolic activation of IQ, and reduces the metabolic activation level of Glu-P-I. Anthraflavic acid may exert anticancer activity by inhibiting the metabolic activation of chemical carcinogens. Anthraflavic acid is applicable to cancer-related research .
Cat. No.: HY-174144
CAS No.: 2851993-73-0
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RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2)(IC50=100 nM). RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases .
Cat. No.: HY-123189
CAS No.: 89139-28-6
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LY 171859 is a D2 receptor agonist with significant reductase activity. LY 171859 exhibits enzymatic activity in the cytoplasm of liver, lung, and kidney, and also contains significant reductase activity in rat and human blood. LY 171859 has higher hepatic reductase activity in guinea pigs, followed by hamsters, rabbits, rats, and mice. The substrate of LY 171859 shows an apparent Km of 5.6 μM. The reduction reaction of LY 171859 is NADPH-dependent with an apparent Km of 14.8 μM. Only the A-side hydrogen of NADPH is incorporated in the reduction product of LY 171859. The reaction of LY 171859 is inhibited by cyanide and thiol reagents, and phenobarbital does not induce its activity in rats .
Cat. No.: HY-187119
CAS No.: 148673-71-6
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CC13401 is an aldose reductase (ALR2) inhibitor with an IC50 of 41.41 μM in rats. CC13401 inhibits the NADPH-dependent reduction reaction catalyzed by ALR2. CC13401 can be used in studies on the mechanisms related to the polyol pathway and diabetic complications .
Cat. No.: HY-E71567
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2-Hydroxymethylglutarate dehydrogenase (EC 1.1.1.291) is an NADPH-dependent D-ribulose reductase—a type of oxidoreductase—that catalyzes the reduction of D-ribulose to D-arabitol. It plays a key role in pentose metabolism, sugar alcohol metabolism, and carbon source utilization in microorganisms and fungi.
Cat. No.: HY-E71772A
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3-Oxo-5-β-steroid 4-dehydrogenase from human (Recombinant) (EC 1.3.1.3) belongs to the NADPH-dependent short-chain dehydrogenase/reductase superfamily (AKR family). It catalyzes the 5β-reduction of the Δ4 double bond in steroid molecules and is involved in bile acid synthesis and steroid hormone metabolism, serving as a crucial enzyme for maintaining hepatic cholesterol metabolism and endocrine homeostasis.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
