84-60-6
Chemical Structure
Anthraflavic acid
- CAS No.: 84-60-6
- Formula:C14H8O4
- Molecular Weight:240.21
IUPAC Name: 2,6-dihydroxyanthracene-9,10-dione
InChIKey: APAJFZPFBHMFQR-UHFFFAOYSA-N
SMILES: O=C1C2=C(C=C(O)C=C2)C(C3=CC=C(O)C=C13)=O
Biological Activity: Anthraflavic acid specifically inhibits the activity of cytochrome P-448 without affecting phenobarbital-induced cytochrome P-450 or NADPH-dependent cytochrome c reduction. Anthraflavic acid inhibits cytosolic metabolic pathways, blocks the microsomal and cytosolic activation of IQ, and reduces the metabolic activation level of Glu-P-I. Anthraflavic acid may exert anticancer activity by inhibiting the metabolic activation of chemical carcinogens. Anthraflavic acid is applicable to cancer-related research[1][2][3].
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Anthraflavic acid | 99.51% | Anthraflavic acid specifically inhibits the activity of cytochrome P-448 without affecting phenobarbital-induced cytochrome P-450 or NADPH-dependent cytochrome c reduction. Anthraflavic acid inhibits cytosolic metabolic pathways, blocks the microsomal and cytosolic activation of IQ, and reduces the metabolic activation level of Glu-P-I. Anthraflavic acid may exert anticancer activity by inhibiting the metabolic activation of chemical carcinogens. Anthraflavic acid is applicable to cancer-related research. | ||||||||||||||||||||
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References
- [1]. Ayrton AD, et al. Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action. Mutat Res. 1988;207(3-4):121-125. [Content Brief]
- [2]. Ayrton AD, et al. Anthraflavic acid is a potent and specific inhibitor of cytochrome P-448 activity. Biochim Biophys Acta. 1987;916(3):328-331. [Content Brief]
- [3]. Ayrton AD, et al. Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid. Food Chem Toxicol. 1988;26(11-12):909-915. [Content Brief]
