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Isoforms Recommended: NEK1
Results for "

NEK1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122639
    ZINC05007751
    3 Publications Verification

    		 NEKs Cancer
    ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9 [1].
    ZINC05007751
  • HY-144425
    BSc5367

    		NEKs Inflammation/Immunology
    BSc5367 is a potent Nek1 inhibitor with an IC50 of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer [1].
    BSc5367
  • HY-103646
    CK7

    		NEKs CDK Others
    CK7, a Cdk2/9 inhibitor, can be used for the synthesis of Nek1 inhibitor BSc5231 and BSc5367 [1].
    CK7
  • HY-RS18625
    Nek1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nek1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nek1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nek1 Mouse Pre-designed siRNA Set A
    Nek1 Mouse Pre-designed siRNA Set A
  • HY-RS25111
    Nek1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nek1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nek1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nek1 Rat Pre-designed siRNA Set A
    Nek1 Rat Pre-designed siRNA Set A
  • HY-RS09190
    NEK1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NEK1 Human Pre-designed siRNA Set A contains three designed siRNAs for NEK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NEK1 Human Pre-designed siRNA Set A
    NEK1 Human Pre-designed siRNA Set A
  • HY-149213
    LSD1/TLK1-IN-1

    J54; J3-54

    		 Histone Demethylase TLK Cancer
    LSD1/TLK1-IN-1 is an orally active LSD1, TLK1, TLK2, TTK inhibitor with an LSD1 IC50 of 0.247 μM. LSD1/TLK1-IN-1 suppresses phosphorylation of Nek1 at T141 and Rad9 at S328, abrogates the TLK1>Nek1>ATR>Chk1 axis, protects H3K4me1/2 from demethylation, and does not affect LSD2, MAO-A, or MAO-B. LSD1/TLK1-IN-1 induces apoptosis, bypasses cell-cycle arrest, suppresses tumor growth, acts as a weak D4R antagonist, downregulates PD-L1 expression, enhances T-cell killing response, inhibits gastric cancer cell proliferation, shows minimal toxicity, and has no significant effect on normal prostate cells. LSD1/TLK1-IN-1 can be used for the research of prostate cancer and gastric cancer [1] .
    LSD1/TLK1-IN-1
  • HY-173186
    TLK1-IN-1

    		TLK Apoptosis Cancer
    TLK1-IN-1 is a TLK1B inhibitor with a human IC50 of 7.2 μM. TLK1-IN-1 causes accumulation of DNA damage and induces apoptotic cell death in cancer cells. TLK1-IN-1 can be used for the research of metastatic castration-resistant prostate cancer [1].
    TLK1-IN-1
  • HY-103646R
    CK7 (Standard)

    		NEKs Reference Standards CDK Others
    CK7 (Standard) is the analytical standard of CK7 (HY-103646). This product is intended for research and analytical applications. CK7, a Cdk2/9 inhibitor, can be used for the synthesis of Nek1 inhibitor BSc5231 and BSc5367 [1].
    CK7 (Standard)

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