NEK1
NEK1 is the largest member of the NIMA-related kinase family, distinguished by an extended C-terminal region beyond its catalytic domain. It localizes to cilia and centrosomes and contributes to regulation of ciliary resorption and to the DNA damage response, where it participates in ATR-mediated checkpoint signaling and repair. NEK1 also influences mitochondrial membrane permeability. Rare loss-of-function variants in NEK1 and its partner C21orf2 are associated with amyotrophic lateral sclerosis, and NEK1 dysfunction has been linked to ciliopathies including retinal degeneration phenotypes. Recombinant NEK1 supports studies of ciliary signaling, genome-stability pathways and neurodegeneration-associated kinase biology.
